Power Doppler harmonic imaging

A feasibility study of a new technique for the assessment of myocardial perfusion

R. Senior, Sanjiv Kaul, P. Soman, A. Lahiri

Research output: Contribution to journalArticle

81 Citations (Scopus)

Abstract

Background: The aim of the study was to assess the feasibility of a new technique, power Doppler harmonic imaging (PDHI), for assessing myocardial perfusion through a venous injection of microbubbles, with the use of a new ultrasound contrast agent. Methods and Results: Fifteen patients with known coronary artery disease and a resting perfusion abnormality on Tc-99m sestamibi single-photon emission computed tomography (SPECT) underwent PDHI at rest during intravenous injections of 2 to 3 mL of Sonovue (Bracco SpA, Milan, Italy), a new second-generation ultrasound contrast agent. Myocardial perfusion was determined to be present or absent by use of a 5-segment model by 2 blinded observers for both PDHI and SPECT. Of a total of 75 possible myocardial segments, 7 (9%) were not analyzed because of obvious artifacts on PDHI. SPECT showed perfusion defects in 40 of the remaining 68 segments, whereas PDHI showed 39 defects. There was high concordance between the 2 imaging modalities for the presence (93%) as well as the location (96% for the anteroseptal region, 93% for the inferoposterior region, and 87% for the apical region) of the defects. Conclusions: These preliminary results suggest that PDHI is a feasible technique for the detection of resting myocardial perfusion defects in patients with coronary artery disease after a venous injection of a new second-generation ultrasound contrast agent.

Original languageEnglish (US)
Pages (from-to)245-251
Number of pages7
JournalAmerican Heart Journal
Volume139
Issue number2 I
StatePublished - 2000
Externally publishedYes

Fingerprint

Feasibility Studies
Perfusion
Single-Photon Emission-Computed Tomography
Contrast Media
Coronary Artery Disease
Microbubbles
Injections
Myocardial Perfusion Imaging
Intravenous Injections
Artifacts
Italy

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

Power Doppler harmonic imaging : A feasibility study of a new technique for the assessment of myocardial perfusion. / Senior, R.; Kaul, Sanjiv; Soman, P.; Lahiri, A.

In: American Heart Journal, Vol. 139, No. 2 I, 2000, p. 245-251.

Research output: Contribution to journalArticle

@article{549d0754155e40a1bac5aa57939cc8ef,
title = "Power Doppler harmonic imaging: A feasibility study of a new technique for the assessment of myocardial perfusion",
abstract = "Background: The aim of the study was to assess the feasibility of a new technique, power Doppler harmonic imaging (PDHI), for assessing myocardial perfusion through a venous injection of microbubbles, with the use of a new ultrasound contrast agent. Methods and Results: Fifteen patients with known coronary artery disease and a resting perfusion abnormality on Tc-99m sestamibi single-photon emission computed tomography (SPECT) underwent PDHI at rest during intravenous injections of 2 to 3 mL of Sonovue (Bracco SpA, Milan, Italy), a new second-generation ultrasound contrast agent. Myocardial perfusion was determined to be present or absent by use of a 5-segment model by 2 blinded observers for both PDHI and SPECT. Of a total of 75 possible myocardial segments, 7 (9{\%}) were not analyzed because of obvious artifacts on PDHI. SPECT showed perfusion defects in 40 of the remaining 68 segments, whereas PDHI showed 39 defects. There was high concordance between the 2 imaging modalities for the presence (93{\%}) as well as the location (96{\%} for the anteroseptal region, 93{\%} for the inferoposterior region, and 87{\%} for the apical region) of the defects. Conclusions: These preliminary results suggest that PDHI is a feasible technique for the detection of resting myocardial perfusion defects in patients with coronary artery disease after a venous injection of a new second-generation ultrasound contrast agent.",
author = "R. Senior and Sanjiv Kaul and P. Soman and A. Lahiri",
year = "2000",
language = "English (US)",
volume = "139",
pages = "245--251",
journal = "American Heart Journal",
issn = "0002-8703",
publisher = "Mosby Inc.",
number = "2 I",

}

TY - JOUR

T1 - Power Doppler harmonic imaging

T2 - A feasibility study of a new technique for the assessment of myocardial perfusion

AU - Senior, R.

AU - Kaul, Sanjiv

AU - Soman, P.

AU - Lahiri, A.

PY - 2000

Y1 - 2000

N2 - Background: The aim of the study was to assess the feasibility of a new technique, power Doppler harmonic imaging (PDHI), for assessing myocardial perfusion through a venous injection of microbubbles, with the use of a new ultrasound contrast agent. Methods and Results: Fifteen patients with known coronary artery disease and a resting perfusion abnormality on Tc-99m sestamibi single-photon emission computed tomography (SPECT) underwent PDHI at rest during intravenous injections of 2 to 3 mL of Sonovue (Bracco SpA, Milan, Italy), a new second-generation ultrasound contrast agent. Myocardial perfusion was determined to be present or absent by use of a 5-segment model by 2 blinded observers for both PDHI and SPECT. Of a total of 75 possible myocardial segments, 7 (9%) were not analyzed because of obvious artifacts on PDHI. SPECT showed perfusion defects in 40 of the remaining 68 segments, whereas PDHI showed 39 defects. There was high concordance between the 2 imaging modalities for the presence (93%) as well as the location (96% for the anteroseptal region, 93% for the inferoposterior region, and 87% for the apical region) of the defects. Conclusions: These preliminary results suggest that PDHI is a feasible technique for the detection of resting myocardial perfusion defects in patients with coronary artery disease after a venous injection of a new second-generation ultrasound contrast agent.

AB - Background: The aim of the study was to assess the feasibility of a new technique, power Doppler harmonic imaging (PDHI), for assessing myocardial perfusion through a venous injection of microbubbles, with the use of a new ultrasound contrast agent. Methods and Results: Fifteen patients with known coronary artery disease and a resting perfusion abnormality on Tc-99m sestamibi single-photon emission computed tomography (SPECT) underwent PDHI at rest during intravenous injections of 2 to 3 mL of Sonovue (Bracco SpA, Milan, Italy), a new second-generation ultrasound contrast agent. Myocardial perfusion was determined to be present or absent by use of a 5-segment model by 2 blinded observers for both PDHI and SPECT. Of a total of 75 possible myocardial segments, 7 (9%) were not analyzed because of obvious artifacts on PDHI. SPECT showed perfusion defects in 40 of the remaining 68 segments, whereas PDHI showed 39 defects. There was high concordance between the 2 imaging modalities for the presence (93%) as well as the location (96% for the anteroseptal region, 93% for the inferoposterior region, and 87% for the apical region) of the defects. Conclusions: These preliminary results suggest that PDHI is a feasible technique for the detection of resting myocardial perfusion defects in patients with coronary artery disease after a venous injection of a new second-generation ultrasound contrast agent.

UR - http://www.scopus.com/inward/record.url?scp=0033952843&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033952843&partnerID=8YFLogxK

M3 - Article

VL - 139

SP - 245

EP - 251

JO - American Heart Journal

JF - American Heart Journal

SN - 0002-8703

IS - 2 I

ER -