Potential therapeutic applications of human anti-Müllerian hormone (AMH) analogues in reproductive medicine

Vitaly A. Kushnir, David B. Seifer, David H. Barad, Aritro Sen, Norbert Gleicher

Research output: Contribution to journalReview articlepeer-review

17 Scopus citations

Abstract

Members of the transforming growth factor-beta (TGF-beta) superfamily are key regulators of various physiological processes. Anti-Müllerian hormone (AMH) which is also commonly known as Müllerian-inhibiting substance (MIS) is a member of the TGF-beta superfamily and an important regulator of reproductive organ differentiation and ovarian follicular development. While AMH has been used for diagnostic purposes as a biomarker for over 15 years, new potential therapeutic applications of recombinant human AMH analogues are now emerging as pharmacologic agents in reproductive medicine. Therapeutic uses of AMH in gonadal tissue may provide a unique opportunity to address a broad range of reproductive themes, like contraception, ovulation induction, onset of menopause, and fertility preservation, as well as specific disease conditions, such as polycystic ovarian syndrome (PCOS) and cancers of the reproductive tract. This review explores the most promising therapeutic applications for a novel class of drugs known as AMH analogues with agonist and antagonist functions.

Original languageEnglish (US)
Pages (from-to)1105-1113
Number of pages9
JournalJournal of Assisted Reproduction and Genetics
Volume34
Issue number9
DOIs
StatePublished - Sep 1 2017

Keywords

  • AMH agonist
  • AMH analogues
  • AMH antagonist
  • Anti-Müllerian hormone
  • Contraception
  • Endometrial cancer
  • Fertility preservation
  • Fertility treatment
  • Menopause
  • Müllerian inhibiting substance
  • Ovarian cancer
  • Ovulation induction
  • Polycystic ovarian syndrome

ASJC Scopus subject areas

  • Reproductive Medicine
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Genetics(clinical)

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