Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection

Qingsheng Li, Jeffrey D. Lifson, Lijie Duan, Timothy W. Schacker, Cavan Reilly, John Carlis, Jacob Estes, Ashley T. Haase

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Osteopontin is a multifunctional protein with known roles in bone remodeling, wound healing, and normal and pathological immune responses. We showed in microarray studies that osteopontin gene expression is increased in human immunodeficiency virus type 1 (HIV-1)-infected lymphatic tissues after treatment, and we undertook mapping experiments to study osteopontin's possible functions in this context. We discovered species-specific colocalization of osteopontin with the follicular dendritic cell (FDC) network in lymphatic tissues in HIV-1 and simian immunodeficiency virus infections, and we found that changes in FDC-associated osteopontin covary with changes in lymphoid follicles during acute and late stages of infection and in response to treatment. We propose that this localization normally facilitates antibody production and plays a role in B cell abnormalities in infection and in the reconstitution of lymphoid follicles with treatment and that mapping genes identified in microarray studies is a useful experimental approach to gaining a better understanding of function in the context of a particular tissue and disease.

Original languageEnglish (US)
Pages (from-to)1269-1276
Number of pages8
JournalJournal of Infectious Diseases
Volume192
Issue number7
DOIs
StatePublished - Sep 1 2005
Externally publishedYes

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Follicular Dendritic Cells
Osteopontin
HIV-1
B-Lymphocytes
Pathology
Infection
Lymphoid Tissue
Simian Immunodeficiency Virus
Bone Remodeling
Chromosome Mapping
Virus Diseases
Wound Healing
Antibody Formation
Gene Expression
Proteins

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Immunology

Cite this

Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection. / Li, Qingsheng; Lifson, Jeffrey D.; Duan, Lijie; Schacker, Timothy W.; Reilly, Cavan; Carlis, John; Estes, Jacob; Haase, Ashley T.

In: Journal of Infectious Diseases, Vol. 192, No. 7, 01.09.2005, p. 1269-1276.

Research output: Contribution to journalArticle

Li, Qingsheng ; Lifson, Jeffrey D. ; Duan, Lijie ; Schacker, Timothy W. ; Reilly, Cavan ; Carlis, John ; Estes, Jacob ; Haase, Ashley T. / Potential roles of follicular dendritic cell-associated osteopontin in lymphoid follicle pathology and repair and in B cell regulation in HIV-1 and SIV infection. In: Journal of Infectious Diseases. 2005 ; Vol. 192, No. 7. pp. 1269-1276.
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