Potential role of the glycolytic oscillator in acute hypoxia in tumors

Leonard Che Fru, Erin B. Adamson, David D. Campos, Sean B. Fain, Steven Jacques, Albert J. Van Der Kogel, Kwang P. Nickel, Chihwa Song, Randall J. Kimple, Michael W. Kissick

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Tumor acute hypoxia has a dynamic component that is also, at least partially, coherent. Using blood oxygen level dependent magnetic resonance imaging, we observed coherent oscillations in hemoglobin saturation dynamics in cell line xenograft models of head and neck squamous cell carcinoma. We posit a well-established biochemical nonlinear oscillatory mechanism called the glycolytic oscillator as a potential cause of the coherent oscillations in tumors. These data suggest that metabolic changes within individual tumor cells may affect the local tumor microenvironment including oxygen availability and therefore radiosensitivity. These individual cells can synchronize the oscillations in patches of similar intermediate glucose levels. These alterations have potentially important implications for radiation therapy and are a potential target for optimizing the cancer response to radiation.

Original languageEnglish (US)
Pages (from-to)9215-9225
Number of pages11
JournalPhysics in Medicine and Biology
Volume60
Issue number24
DOIs
StatePublished - Nov 17 2015

Fingerprint

Oxygen
Neoplasms
Tumor Microenvironment
Radiation Tolerance
Heterografts
Hemoglobins
Radiotherapy
Magnetic Resonance Imaging
Radiation
Glucose
Cell Line
Tumor Hypoxia
Carcinoma, squamous cell of head and neck

Keywords

  • acute hypoxia
  • BOLD
  • glycolytic oscillator
  • MRI
  • radiation
  • radiosensitivity
  • tumor

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Fru, L. C., Adamson, E. B., Campos, D. D., Fain, S. B., Jacques, S., Van Der Kogel, A. J., ... Kissick, M. W. (2015). Potential role of the glycolytic oscillator in acute hypoxia in tumors. Physics in Medicine and Biology, 60(24), 9215-9225. https://doi.org/10.1088/0031-9155/60/24/9215

Potential role of the glycolytic oscillator in acute hypoxia in tumors. / Fru, Leonard Che; Adamson, Erin B.; Campos, David D.; Fain, Sean B.; Jacques, Steven; Van Der Kogel, Albert J.; Nickel, Kwang P.; Song, Chihwa; Kimple, Randall J.; Kissick, Michael W.

In: Physics in Medicine and Biology, Vol. 60, No. 24, 17.11.2015, p. 9215-9225.

Research output: Contribution to journalArticle

Fru, LC, Adamson, EB, Campos, DD, Fain, SB, Jacques, S, Van Der Kogel, AJ, Nickel, KP, Song, C, Kimple, RJ & Kissick, MW 2015, 'Potential role of the glycolytic oscillator in acute hypoxia in tumors', Physics in Medicine and Biology, vol. 60, no. 24, pp. 9215-9225. https://doi.org/10.1088/0031-9155/60/24/9215
Fru LC, Adamson EB, Campos DD, Fain SB, Jacques S, Van Der Kogel AJ et al. Potential role of the glycolytic oscillator in acute hypoxia in tumors. Physics in Medicine and Biology. 2015 Nov 17;60(24):9215-9225. https://doi.org/10.1088/0031-9155/60/24/9215
Fru, Leonard Che ; Adamson, Erin B. ; Campos, David D. ; Fain, Sean B. ; Jacques, Steven ; Van Der Kogel, Albert J. ; Nickel, Kwang P. ; Song, Chihwa ; Kimple, Randall J. ; Kissick, Michael W. / Potential role of the glycolytic oscillator in acute hypoxia in tumors. In: Physics in Medicine and Biology. 2015 ; Vol. 60, No. 24. pp. 9215-9225.
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