Potential role of insulin in the clearance of remnant lipoproteins in dysbetalipoproteinaemia

Paul Duell, E. L. Bierman

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Dysbetalipoproteinaemia is a genetic disorder characterized by accumulation of lipoprotein remnant particles in the plasma, accelerated atherosclerosis, and the abnormal apoprotein E2. Uncontrolled diabetes mellitus can aggravate the hyperlipidaemia associated with this disorder, presumably by increasing triglyceride synthesis and reducing very low density lipoprotein catabolism by lipoprotein lipase. This report documents the gradual amelioration of dysbetalipoproteinaemia in uncontrolled diabetes mellitus following therapy with exogenous insulin alone. Although the beneficial effects of insulin therapy in this patient may include inhibition of triglyceride synthesis and improved triglyceride catabolism, we propose that insulin may also stimulate clearance of atherogenic remnant lipoprotein particles.

Original languageEnglish (US)
Pages (from-to)97-101
Number of pages5
JournalJournal of Internal Medicine
Volume229
Issue number1
StatePublished - 1991
Externally publishedYes

Fingerprint

Hyperlipoproteinemia Type III
Lipoproteins
Triglycerides
Insulin
Diabetes Mellitus
Inborn Genetic Diseases
Apoproteins
VLDL Lipoproteins
Lipoprotein Lipase
Hyperlipidemias
Atherosclerosis
Therapeutics

Keywords

  • Diabetes mellitus
  • Dysbetalipoproteinaemia
  • Insulin
  • Remnant lipoproteins
  • Type III hyperlipidaemia

ASJC Scopus subject areas

  • Internal Medicine

Cite this

Potential role of insulin in the clearance of remnant lipoproteins in dysbetalipoproteinaemia. / Duell, Paul; Bierman, E. L.

In: Journal of Internal Medicine, Vol. 229, No. 1, 1991, p. 97-101.

Research output: Contribution to journalArticle

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