Potential mechanisms for racial and ethnic differences in antimüllerian hormone and ovarian reserve

Reshef Tal, David Seifer

Research output: Contribution to journalArticle

39 Citations (Scopus)

Abstract

Accumulating evidence suggests that reproductive potential and function may be different across racial and ethnic groups. Racial differences have been demonstrated in pubertal timing, infertility, outcomes after assisted reproductive technology (ART) treatment, and reproductive aging. Recently, racial differences have also been described in serum antimüllerian hormone (AMH), a sensitive biomarker of ovarian reserve, supporting the notion that ovarian reserve differs between racial/ethnic groups. The existence of such racial/ethnic differences in ovarian reserve, as reflected by AMH, may have important clinical implications for reproductive endocrinologists. However, the mechanisms which may underlie such racial differences in ovarian reserve are unclear. Various genetic factors and environmental factors such as obesity, smoking, and vitamin D deficiency which have been shown to correlate with serum AMH levels and also display significant racial/ethnic variations are discussed in this review. Improving our understanding of racial differences in ovarian reserve and their underlying causes may be essential for infertility treatment in minority women and lead to better reproductive planning, improved treatment outcomes, and timely interventions which may prolong reproductive lifespan in these women.

Original languageEnglish (US)
Article number818912
JournalInternational Journal of Endocrinology
Volume2013
DOIs
StatePublished - 2013
Externally publishedYes

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Hormones
Ethnic Groups
Infertility
Assisted Reproductive Techniques
Vitamin D Deficiency
Serum
Obesity
Biomarkers
Smoking
Ovarian Reserve
Therapeutics

ASJC Scopus subject areas

  • Endocrine and Autonomic Systems
  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Potential mechanisms for racial and ethnic differences in antimüllerian hormone and ovarian reserve. / Tal, Reshef; Seifer, David.

In: International Journal of Endocrinology, Vol. 2013, 818912, 2013.

Research output: Contribution to journalArticle

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