Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28

Christoph Kahl, Jessica Bonnell, Suja Hiriyanna, Megan Fultz, Cassandra Nyberg-Hoffman, Ping Chen, C. Richter King, Jason G D Gall

    Research output: Contribution to journalArticle

    38 Citations (Scopus)

    Abstract

    Adenovirus vaccine vectors derived from rare human serotypes have been shown to be less potent than serotype 5 (Ad5) at inducing immune responses to encoded antigens. To identify highly immunogenic adenovirus vectors, we assessed pro-inflammatory cytokine expression, binding to the CD46 receptor, and immunogenicity. Species D adenoviruses uniquely suppressed pro-inflammatory cytokines and induced high levels of type I interferon. Thus, it was unexpected that a vector derived from a representative serotype, Ad28, induced significantly higher transgene-specific T cell responses than an Ad35 vector. Prime-boost regimens with Ad28, Ad35, Ad14, or Ad5 significantly boosted T cell and antibody responses. The seroprevalence of Ad28 was confirmed to be

    Original languageEnglish (US)
    Pages (from-to)5691-5702
    Number of pages12
    JournalVaccine
    Volume28
    Issue number35
    DOIs
    StatePublished - Aug 2010

    Fingerprint

    Adenovirus Vaccines
    vector vaccines
    Adenoviridae
    serotypes
    cytokines
    immune response
    Cytokines
    T-lymphocytes
    T-Lymphocytes
    Interferon Type I
    Seroepidemiologic Studies
    interferons
    Transgenes
    seroprevalence
    transgenes
    Antibody Formation
    antigens
    Antigens
    receptors
    antibodies

    Keywords

    • Adenovirus
    • Human vaccine
    • Seroprevalence
    • Vector

    ASJC Scopus subject areas

    • Immunology and Microbiology(all)
    • Infectious Diseases
    • Public Health, Environmental and Occupational Health
    • veterinary(all)
    • Molecular Medicine
    • Medicine(all)

    Cite this

    Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28. / Kahl, Christoph; Bonnell, Jessica; Hiriyanna, Suja; Fultz, Megan; Nyberg-Hoffman, Cassandra; Chen, Ping; King, C. Richter; Gall, Jason G D.

    In: Vaccine, Vol. 28, No. 35, 08.2010, p. 5691-5702.

    Research output: Contribution to journalArticle

    Kahl, C, Bonnell, J, Hiriyanna, S, Fultz, M, Nyberg-Hoffman, C, Chen, P, King, CR & Gall, JGD 2010, 'Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28', Vaccine, vol. 28, no. 35, pp. 5691-5702. https://doi.org/10.1016/j.vaccine.2010.06.050
    Kahl, Christoph ; Bonnell, Jessica ; Hiriyanna, Suja ; Fultz, Megan ; Nyberg-Hoffman, Cassandra ; Chen, Ping ; King, C. Richter ; Gall, Jason G D. / Potent immune responses and in vitro pro-inflammatory cytokine suppression by a novel adenovirus vaccine vector based on rare human serotype 28. In: Vaccine. 2010 ; Vol. 28, No. 35. pp. 5691-5702.
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