Potassium modulation of corticosterone secretion from perifused mouse adrenal cells

Linda M. Robertson, L. Donald Keith, John Kendall

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Potassium has long been recognized as a significant modulator of aldosterone synthesis and secretion. Its role as a regulator of glucocorticoids is less clear. Using a perifusion of dispersed mouse adrenal cells, we found a dose-related effect of extracellular potassium (K+) on secretion of the major rodent glucocorticoid, corticosterone. The maximal elicitable response was 33% of the maximal response to ACTH. An increase in K+ concentration enhanced the effect of ACTH, while K+-free medium depressed the response to ACTH. The temporal characteristics of the corticosterone response to K+ were similar to that of ACTH and consistent with a primary effect on biosynthesis rather than on discharge of a preformed pool of hormone. The results indicate that a significant ion-mediated mechanism modulates ACTH-stimulated glucocorticoid secretion and suggest that further studies of endogenous substances operative by ionic mechanisms might be warranted.

Original languageEnglish (US)
Pages (from-to)703-709
Number of pages7
JournalMetabolism
Volume33
Issue number8
DOIs
StatePublished - 1984

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Corticosterone
Adrenocorticotropic Hormone
Potassium
Glucocorticoids
Aldosterone
Rodentia
Hormones
Ions

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

Cite this

Potassium modulation of corticosterone secretion from perifused mouse adrenal cells. / Robertson, Linda M.; Keith, L. Donald; Kendall, John.

In: Metabolism, Vol. 33, No. 8, 1984, p. 703-709.

Research output: Contribution to journalArticle

Robertson, Linda M. ; Keith, L. Donald ; Kendall, John. / Potassium modulation of corticosterone secretion from perifused mouse adrenal cells. In: Metabolism. 1984 ; Vol. 33, No. 8. pp. 703-709.
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