Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

Catherine M. Clase, Juan Jesus Carrero, David H. Ellison, Morgan E. Grams, Brenda R. Hemmelgarn, Meg J. Jardine, Csaba P. Kovesdy, Gregory A. Kline, Gregor Lindner, Gregorio T. Obrador, Biff F. Palmer, Michael Cheung, David C. Wheeler, Wolfgang C. Winkelmayer, Roberto Pecoits-Filho, Gloria E. Ashuntantang, Stephan J.L. Bakker, George L. Bakris, Sunil Bhandari, Emmanuel A. BurdmannKatrina L. Campbell, David M. Charytan, Deborah J. Clegg, Lilian Cuppari, David Goldsmith, Stein I. Hallan, Jiang He, Charles A. Herzog, Melanie P. Hoenig, Ewout J. Hoorn, Jens Georg Leipziger, Amanda K. Leonberg-Yoo, Edgar V. Lerma, Jose Ernesto Lopez-Almaraz, Jolanta Małyszko, Johannes F.E. Mann, Matti Marklund, Alicia A. McDonough, Masahiko Nagahama, Sankar D. Navaneethan, Bertram Pitt, Oleh M. Pochynyuk, Thyago Proença de Moraes, Zubaid Rafique, Bruce M. Robinson, Simon D. Roger, Patrick Rossignol, Adam J. Singer, Andrew Smyth, Manish M. Sood, Michael Walsh, Matthew R. Weir, Charles S. Wingo

Research output: Contribution to journalArticle

Abstract

Potassium disorders are common in patients with kidney disease, particularly in patients with tubular disorders and low glomerular filtration rate. A multidisciplinary group of researchers and clinicians met in October 2018 to identify evidence and address controversies in potassium management. The issues discussed encompassed our latest understanding of the regulation of tubular potassium excretion in health and disease; the relationship of potassium intake to cardiovascular and kidney outcomes, with increasing evidence showing beneficial associations with plant-based diet and data to suggest a paradigm shift from the idea of dietary restriction toward fostering patterns of eating that are associated with better outcomes; the paucity of data on the effect of dietary modification in restoring abnormal serum potassium to the normal range; a novel diagnostic algorithm for hypokalemia that takes into account the ascendency of the clinical context in determining cause, aligning the educational strategy with a practical approach to diagnosis; and therapeutic approaches in managing hyperkalemia when chronic and in the emergency or hospital ward. In sum, we provide here our conference deliberations on potassium homeostasis in health and disease, guidance for evaluation and management of dyskalemias in the context of kidney diseases, and research priorities in each of the above areas.

Original languageEnglish (US)
Pages (from-to)42-61
Number of pages20
JournalKidney International
Volume97
Issue number1
DOIs
StatePublished - Jan 2020

Fingerprint

Kidney Diseases
Potassium
Homeostasis
Diet Therapy
Hyperkalemia
Foster Home Care
Hypokalemia
Health
Glomerular Filtration Rate
Reference Values
Emergencies
Eating
Research Personnel
Diet
Kidney
Serum
Research

Keywords

  • acute hyperkalemia
  • chronic hyperkalemia
  • dietary potassium
  • hypokalemia
  • plasma potassium
  • potassium homeostasis
  • serum potassium

ASJC Scopus subject areas

  • Nephrology

Cite this

Potassium homeostasis and management of dyskalemia in kidney diseases : conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. / Clase, Catherine M.; Carrero, Juan Jesus; Ellison, David H.; Grams, Morgan E.; Hemmelgarn, Brenda R.; Jardine, Meg J.; Kovesdy, Csaba P.; Kline, Gregory A.; Lindner, Gregor; Obrador, Gregorio T.; Palmer, Biff F.; Cheung, Michael; Wheeler, David C.; Winkelmayer, Wolfgang C.; Pecoits-Filho, Roberto; Ashuntantang, Gloria E.; Bakker, Stephan J.L.; Bakris, George L.; Bhandari, Sunil; Burdmann, Emmanuel A.; Campbell, Katrina L.; Charytan, David M.; Clegg, Deborah J.; Cuppari, Lilian; Goldsmith, David; Hallan, Stein I.; He, Jiang; Herzog, Charles A.; Hoenig, Melanie P.; Hoorn, Ewout J.; Leipziger, Jens Georg; Leonberg-Yoo, Amanda K.; Lerma, Edgar V.; Lopez-Almaraz, Jose Ernesto; Małyszko, Jolanta; Mann, Johannes F.E.; Marklund, Matti; McDonough, Alicia A.; Nagahama, Masahiko; Navaneethan, Sankar D.; Pitt, Bertram; Pochynyuk, Oleh M.; Proença de Moraes, Thyago; Rafique, Zubaid; Robinson, Bruce M.; Roger, Simon D.; Rossignol, Patrick; Singer, Adam J.; Smyth, Andrew; Sood, Manish M.; Walsh, Michael; Weir, Matthew R.; Wingo, Charles S.

In: Kidney International, Vol. 97, No. 1, 01.2020, p. 42-61.

Research output: Contribution to journalArticle

Clase, CM, Carrero, JJ, Ellison, DH, Grams, ME, Hemmelgarn, BR, Jardine, MJ, Kovesdy, CP, Kline, GA, Lindner, G, Obrador, GT, Palmer, BF, Cheung, M, Wheeler, DC, Winkelmayer, WC, Pecoits-Filho, R, Ashuntantang, GE, Bakker, SJL, Bakris, GL, Bhandari, S, Burdmann, EA, Campbell, KL, Charytan, DM, Clegg, DJ, Cuppari, L, Goldsmith, D, Hallan, SI, He, J, Herzog, CA, Hoenig, MP, Hoorn, EJ, Leipziger, JG, Leonberg-Yoo, AK, Lerma, EV, Lopez-Almaraz, JE, Małyszko, J, Mann, JFE, Marklund, M, McDonough, AA, Nagahama, M, Navaneethan, SD, Pitt, B, Pochynyuk, OM, Proença de Moraes, T, Rafique, Z, Robinson, BM, Roger, SD, Rossignol, P, Singer, AJ, Smyth, A, Sood, MM, Walsh, M, Weir, MR & Wingo, CS 2020, 'Potassium homeostasis and management of dyskalemia in kidney diseases: conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference', Kidney International, vol. 97, no. 1, pp. 42-61. https://doi.org/10.1016/j.kint.2019.09.018
Clase, Catherine M. ; Carrero, Juan Jesus ; Ellison, David H. ; Grams, Morgan E. ; Hemmelgarn, Brenda R. ; Jardine, Meg J. ; Kovesdy, Csaba P. ; Kline, Gregory A. ; Lindner, Gregor ; Obrador, Gregorio T. ; Palmer, Biff F. ; Cheung, Michael ; Wheeler, David C. ; Winkelmayer, Wolfgang C. ; Pecoits-Filho, Roberto ; Ashuntantang, Gloria E. ; Bakker, Stephan J.L. ; Bakris, George L. ; Bhandari, Sunil ; Burdmann, Emmanuel A. ; Campbell, Katrina L. ; Charytan, David M. ; Clegg, Deborah J. ; Cuppari, Lilian ; Goldsmith, David ; Hallan, Stein I. ; He, Jiang ; Herzog, Charles A. ; Hoenig, Melanie P. ; Hoorn, Ewout J. ; Leipziger, Jens Georg ; Leonberg-Yoo, Amanda K. ; Lerma, Edgar V. ; Lopez-Almaraz, Jose Ernesto ; Małyszko, Jolanta ; Mann, Johannes F.E. ; Marklund, Matti ; McDonough, Alicia A. ; Nagahama, Masahiko ; Navaneethan, Sankar D. ; Pitt, Bertram ; Pochynyuk, Oleh M. ; Proença de Moraes, Thyago ; Rafique, Zubaid ; Robinson, Bruce M. ; Roger, Simon D. ; Rossignol, Patrick ; Singer, Adam J. ; Smyth, Andrew ; Sood, Manish M. ; Walsh, Michael ; Weir, Matthew R. ; Wingo, Charles S. / Potassium homeostasis and management of dyskalemia in kidney diseases : conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference. In: Kidney International. 2020 ; Vol. 97, No. 1. pp. 42-61.
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abstract = "Potassium disorders are common in patients with kidney disease, particularly in patients with tubular disorders and low glomerular filtration rate. A multidisciplinary group of researchers and clinicians met in October 2018 to identify evidence and address controversies in potassium management. The issues discussed encompassed our latest understanding of the regulation of tubular potassium excretion in health and disease; the relationship of potassium intake to cardiovascular and kidney outcomes, with increasing evidence showing beneficial associations with plant-based diet and data to suggest a paradigm shift from the idea of dietary restriction toward fostering patterns of eating that are associated with better outcomes; the paucity of data on the effect of dietary modification in restoring abnormal serum potassium to the normal range; a novel diagnostic algorithm for hypokalemia that takes into account the ascendency of the clinical context in determining cause, aligning the educational strategy with a practical approach to diagnosis; and therapeutic approaches in managing hyperkalemia when chronic and in the emergency or hospital ward. In sum, we provide here our conference deliberations on potassium homeostasis in health and disease, guidance for evaluation and management of dyskalemias in the context of kidney diseases, and research priorities in each of the above areas.",
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T2 - conclusions from a Kidney Disease: Improving Global Outcomes (KDIGO) Controversies Conference

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AU - Grams, Morgan E.

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AU - Jardine, Meg J.

AU - Kovesdy, Csaba P.

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AU - Obrador, Gregorio T.

AU - Palmer, Biff F.

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AU - Lerma, Edgar V.

AU - Lopez-Almaraz, Jose Ernesto

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AU - McDonough, Alicia A.

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AU - Navaneethan, Sankar D.

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AU - Pochynyuk, Oleh M.

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AU - Smyth, Andrew

AU - Sood, Manish M.

AU - Walsh, Michael

AU - Weir, Matthew R.

AU - Wingo, Charles S.

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KW - chronic hyperkalemia

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KW - hypokalemia

KW - plasma potassium

KW - potassium homeostasis

KW - serum potassium

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