Potassium concentration changes in the transverse tubules of vertebrate skeletal muscle

Wolfhard Almers

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Vertebrate skeletal muscle fibers have evolved a network of narrow tube-like invaginations of the cell membrane. This 'transverse tubular system' (TTS) provides a pathway for radial impulse propagation from the cell surface to the interior. As a consequence of electrical activity in the TTS, impulses are followed by 'early' and 'late' afterdepolarizations. The late afterdepolarization is now believed to be due mainly to K+-accumulation in the TTS. Excessively large afterdepolarizations of this type may be the cause of the 'myotonic discharge' observed in mammals suffering from pathologically low muscle membrane permeability to chloride. Potassium concentration changes in the transverse tubular system can also be induced artificially under voltage-clamp conditions. Analysis of K+-depletion under voltage clamp allows conclusions about the localization of K+-permeability as well as speed of K+-diffusion in the transverse tubules.

Original languageEnglish (US)
Pages (from-to)1527-1532
Number of pages6
JournalFederation Proceedings
Volume39
Issue number5
StatePublished - 1980
Externally publishedYes

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Vertebrates
Permeability
Potassium
Skeletal Muscle
Skeletal Muscle Fibers
Chlorides
Mammals
Cell Membrane
Muscles
Membranes

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Potassium concentration changes in the transverse tubules of vertebrate skeletal muscle. / Almers, Wolfhard.

In: Federation Proceedings, Vol. 39, No. 5, 1980, p. 1527-1532.

Research output: Contribution to journalArticle

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