Postsynaptic modulation of electrical EPSP size investigated using a compartmental model

Ovidiu Iancu, Jianmei Zhang, Patrick D. Roberts, Curtis C. Bell

Research output: Contribution to journalArticle

Abstract

The mormyrid electric fish displays extremely fine temporal resolution as measured in behavioral studies. The first stage of sensory processing, the sensory afferents, also display very precise temporal responses to electrical stimulation. The afferents are connected through gap junctions to the granular cells, which in addition receive a corollary discharge signal at the time of the electric pulse. The granular cells have a relatively long time constant, seemingly at odds with their presumed role as coincidence detectors. We use experimental data to build a compartmental model that investigates the mechanism by which the relative timing of the two inputs to the granular cells determines the effect of the afferent spike through the electrical synapse.

Original languageEnglish (US)
Pages (from-to)1685-1688
Number of pages4
JournalNeurocomputing
Volume70
Issue number10-12
DOIs
StatePublished - Jun 2007

Fingerprint

Excitatory Postsynaptic Potentials
Fish
Modulation
Electric Fish
Detectors
Processing
Electrical Synapses
Gap Junctions
Electric Stimulation

Keywords

  • Coincidence detection
  • Compartmental model
  • Electrosensory
  • Simulation

ASJC Scopus subject areas

  • Artificial Intelligence
  • Cellular and Molecular Neuroscience

Cite this

Postsynaptic modulation of electrical EPSP size investigated using a compartmental model. / Iancu, Ovidiu; Zhang, Jianmei; Roberts, Patrick D.; Bell, Curtis C.

In: Neurocomputing, Vol. 70, No. 10-12, 06.2007, p. 1685-1688.

Research output: Contribution to journalArticle

Iancu, Ovidiu ; Zhang, Jianmei ; Roberts, Patrick D. ; Bell, Curtis C. / Postsynaptic modulation of electrical EPSP size investigated using a compartmental model. In: Neurocomputing. 2007 ; Vol. 70, No. 10-12. pp. 1685-1688.
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