Postretrieval propranolol disrupts a cocaine conditioned place preference

Rick E. Bernardi, Kennon M. Lattal, Stephen P. Berger

Research output: Contribution to journalArticle

97 Scopus citations

Abstract

The current study examined whether a postretrieval drug memory could be disrupted by the β-adrenoceptor antagonist propranolol, administered following reactivation in a cocaine-mediated conditioned place preference paradigm. Following cocaine conditioning, rats were given a test of conditioned place preference, followed immediately by intraperitoneal administration of propranolol or saline. Rats that received propranolol following the preference test showed no preference for the cocaine-paired floor during a subsequent test, while vehicle-treated rats continued to express a preference for the cocaine-paired floor. These deficits in behavior were specific to retrieval of the cocaine-mediated memory, suggesting that postretrieval propranolol induced an impairment of drug-seeking behavior that is consistent with the disruption of a reconsolidation phase following retrieval.

Original languageEnglish (US)
Pages (from-to)1443-1447
Number of pages5
JournalNeuroReport
Volume17
Issue number13
DOIs
StatePublished - Sep 1 2006

Keywords

  • Cocaine
  • Conditioned place preference
  • Memory
  • Reconsolidation

ASJC Scopus subject areas

  • Neuroscience(all)

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