Postnatal dexamethasone (DEX) increases Functional Residual Capacity (FRC) and respiratory compliance (CRS) in both preterm females and males

Cynthia (Cindy) McEvoy, S. Bowling, K. Williamson, P. McGaw, M. Durand

Research output: Contribution to journalArticle

Abstract

We have previously reported that preterm intubated infants demonstrate a significant increase in FRC and CRS when given a 7 day weaning course of DEX (Ped Res1996;39:229). To our knowledge the effect of gender on UK response to DEX in terms of FRC or CRS has not been reported. We reviewed gender response to DEX in an ongoing blinded, randomized trial comparing the eftect of two dosing regimes of DEX (7 day weaning courses, starting at 0.5 mg/kg/day vs 0.2 mg/kg/day) on FRC and CRS given to intubated very low birth weight (VLBW) infants at 7 to 14 days of age. Twenty-two infants were female (mean BW=710 g; GA=25.6 wks; 64% Caucasian; 32% treated with prenatal corticosteroids; postnatal age =10.1 d; 50% getting 0.5 mg course of DEX; mean airway pressure=6.7 cm H2O; mean FIO2>30%) and 26 were male (mean BW=847g; GA=25.7 wks, 50% Caucasian; 32% treated with prenatal corticosteroids; postnatal age =8.8 d; 62% getting 0.5 mg DEX; mean airway pressure=8.0 cm H2O: mean FIO2> 30%). Pulmonary function testing was done prior to DEX, and on days 2,5, and 7. FRC was measured with the nitrogen washout technique. A minimum of two measurements were performed with the neonate supine and quiet. A study was acceptable if the measurement had a coefficient of variation (CV) of <10%.Crs was measured with the single breath occlusion technique (SensorMedics 2600). A minimum of 10 breaths with a C V of

Original languageEnglish (US)
JournalJournal of Investigative Medicine
Volume47
Issue number2
StatePublished - Feb 1999
Externally publishedYes

Fingerprint

Functional Residual Capacity
Dexamethasone
Compliance
Weaning
Adrenal Cortex Hormones
Pressure
Very Low Birth Weight Infant
Premature Infants
Nitrogen
Newborn Infant
Lung
Testing

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Postnatal dexamethasone (DEX) increases Functional Residual Capacity (FRC) and respiratory compliance (CRS) in both preterm females and males. / McEvoy, Cynthia (Cindy); Bowling, S.; Williamson, K.; McGaw, P.; Durand, M.

In: Journal of Investigative Medicine, Vol. 47, No. 2, 02.1999.

Research output: Contribution to journalArticle

@article{4af31de521934ddb842f63bab41663e4,
title = "Postnatal dexamethasone (DEX) increases Functional Residual Capacity (FRC) and respiratory compliance (CRS) in both preterm females and males",
abstract = "We have previously reported that preterm intubated infants demonstrate a significant increase in FRC and CRS when given a 7 day weaning course of DEX (Ped Res1996;39:229). To our knowledge the effect of gender on UK response to DEX in terms of FRC or CRS has not been reported. We reviewed gender response to DEX in an ongoing blinded, randomized trial comparing the eftect of two dosing regimes of DEX (7 day weaning courses, starting at 0.5 mg/kg/day vs 0.2 mg/kg/day) on FRC and CRS given to intubated very low birth weight (VLBW) infants at 7 to 14 days of age. Twenty-two infants were female (mean BW=710 g; GA=25.6 wks; 64{\%} Caucasian; 32{\%} treated with prenatal corticosteroids; postnatal age =10.1 d; 50{\%} getting 0.5 mg course of DEX; mean airway pressure=6.7 cm H2O; mean FIO2>30{\%}) and 26 were male (mean BW=847g; GA=25.7 wks, 50{\%} Caucasian; 32{\%} treated with prenatal corticosteroids; postnatal age =8.8 d; 62{\%} getting 0.5 mg DEX; mean airway pressure=8.0 cm H2O: mean FIO2> 30{\%}). Pulmonary function testing was done prior to DEX, and on days 2,5, and 7. FRC was measured with the nitrogen washout technique. A minimum of two measurements were performed with the neonate supine and quiet. A study was acceptable if the measurement had a coefficient of variation (CV) of <10{\%}.Crs was measured with the single breath occlusion technique (SensorMedics 2600). A minimum of 10 breaths with a C V of",
author = "McEvoy, {Cynthia (Cindy)} and S. Bowling and K. Williamson and P. McGaw and M. Durand",
year = "1999",
month = "2",
language = "English (US)",
volume = "47",
journal = "Journal of Investigative Medicine",
issn = "1081-5589",
publisher = "Lippincott Williams and Wilkins",
number = "2",

}

TY - JOUR

T1 - Postnatal dexamethasone (DEX) increases Functional Residual Capacity (FRC) and respiratory compliance (CRS) in both preterm females and males

AU - McEvoy, Cynthia (Cindy)

AU - Bowling, S.

AU - Williamson, K.

AU - McGaw, P.

AU - Durand, M.

PY - 1999/2

Y1 - 1999/2

N2 - We have previously reported that preterm intubated infants demonstrate a significant increase in FRC and CRS when given a 7 day weaning course of DEX (Ped Res1996;39:229). To our knowledge the effect of gender on UK response to DEX in terms of FRC or CRS has not been reported. We reviewed gender response to DEX in an ongoing blinded, randomized trial comparing the eftect of two dosing regimes of DEX (7 day weaning courses, starting at 0.5 mg/kg/day vs 0.2 mg/kg/day) on FRC and CRS given to intubated very low birth weight (VLBW) infants at 7 to 14 days of age. Twenty-two infants were female (mean BW=710 g; GA=25.6 wks; 64% Caucasian; 32% treated with prenatal corticosteroids; postnatal age =10.1 d; 50% getting 0.5 mg course of DEX; mean airway pressure=6.7 cm H2O; mean FIO2>30%) and 26 were male (mean BW=847g; GA=25.7 wks, 50% Caucasian; 32% treated with prenatal corticosteroids; postnatal age =8.8 d; 62% getting 0.5 mg DEX; mean airway pressure=8.0 cm H2O: mean FIO2> 30%). Pulmonary function testing was done prior to DEX, and on days 2,5, and 7. FRC was measured with the nitrogen washout technique. A minimum of two measurements were performed with the neonate supine and quiet. A study was acceptable if the measurement had a coefficient of variation (CV) of <10%.Crs was measured with the single breath occlusion technique (SensorMedics 2600). A minimum of 10 breaths with a C V of

AB - We have previously reported that preterm intubated infants demonstrate a significant increase in FRC and CRS when given a 7 day weaning course of DEX (Ped Res1996;39:229). To our knowledge the effect of gender on UK response to DEX in terms of FRC or CRS has not been reported. We reviewed gender response to DEX in an ongoing blinded, randomized trial comparing the eftect of two dosing regimes of DEX (7 day weaning courses, starting at 0.5 mg/kg/day vs 0.2 mg/kg/day) on FRC and CRS given to intubated very low birth weight (VLBW) infants at 7 to 14 days of age. Twenty-two infants were female (mean BW=710 g; GA=25.6 wks; 64% Caucasian; 32% treated with prenatal corticosteroids; postnatal age =10.1 d; 50% getting 0.5 mg course of DEX; mean airway pressure=6.7 cm H2O; mean FIO2>30%) and 26 were male (mean BW=847g; GA=25.7 wks, 50% Caucasian; 32% treated with prenatal corticosteroids; postnatal age =8.8 d; 62% getting 0.5 mg DEX; mean airway pressure=8.0 cm H2O: mean FIO2> 30%). Pulmonary function testing was done prior to DEX, and on days 2,5, and 7. FRC was measured with the nitrogen washout technique. A minimum of two measurements were performed with the neonate supine and quiet. A study was acceptable if the measurement had a coefficient of variation (CV) of <10%.Crs was measured with the single breath occlusion technique (SensorMedics 2600). A minimum of 10 breaths with a C V of

UR - http://www.scopus.com/inward/record.url?scp=33750099866&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=33750099866&partnerID=8YFLogxK

M3 - Article

VL - 47

JO - Journal of Investigative Medicine

JF - Journal of Investigative Medicine

SN - 1081-5589

IS - 2

ER -