Postnatal arsenic exposure and attention impairment in school children

Miguel Rodríguez-Barranco, Fernando Gil, Antonio F. Hernández, Juan Alguacil, Andres Lorca, Ramón Mendoza, Inmaculada Gómez, Isabel Molina-Villalba, Beatriz González-Alzaga, Clemente Aguilar-Garduño, Diane Rohlman, Marina Lacasaña

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Over the last few decades there has been an increased concern about the health risks from exposure to metallic trace elements, including arsenic, because of their potential neurotoxic effects on the developing brain. This study assessed whether urinary arsenic (UA) levels are associated with attention performance and Attention-Deficit/Hyperactivity Disorder (ADHD) in children living in an area with high industrial and mining activities in Southwestern Spain. A cross-sectional study was conducted on 261 children aged 6-9 years. Arsenic levels were determined in urine samples. Attention was measured by using 4 independent tools: a) tests from the Behavioral Assessment and Research System (BARS) designed to measure attention function: Simple Reaction Time Test (RTT), Continuous Performance Test (CPT) and Selective Attention Test (SAT); b) AULA Test, a virtual reality (VR)-based test that evaluates children's response to several stimuli in an environment simulating a classroom; c) Child Behavior Checklist (CBCL), administered to parents; and d) Teacher's Report Form (TRF), administered to teachers. Multivariate linear and logistic regression models, adjusted for potential confounders, were used to estimate the magnitude of the association between UA levels and attention performance scores. Higher UA levels were associated with an increased latency of response in RTT (β = 12.3; 95% confidence interval (CI): 3.5-21.1) and SAT (β = 3.6; 95% CI: .4-6.8) as well as with worse performance on selective and focalized attention in the AULA test (β for impulsivity = .6; 95% CI: .1-1.1; β for inattention = .5; 95% CI: .03-1.0). A dose-response relationship was observed between UA levels and inattention and impulsivity scores. In contrast, results from the CBCL and TRF tests failed to show a significant association with UA levels. In conclusion, UA levels were associated with impaired attention/cognitive function, even at levels considered safe. These results provide additional evidence that postnatal arsenic exposure impairs neurological function in children.

Original languageEnglish (US)
Pages (from-to)370-382
Number of pages13
JournalCortex
Volume74
DOIs
StatePublished - Jan 1 2016

Fingerprint

Arsenic
Confidence Intervals
Reaction Time
Impulsive Behavior
Child Behavior
Checklist
Logistic Models
Behavioral Research
Trace Elements
Attention Deficit Disorder with Hyperactivity
Spain
Cognition
Linear Models
Cross-Sectional Studies
Parents
Urine
Health
Brain

Keywords

  • ADHD
  • Arsenic
  • Attention
  • Children
  • Neurobehavioral disorder
  • Neurotoxicity

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

Cite this

Rodríguez-Barranco, M., Gil, F., Hernández, A. F., Alguacil, J., Lorca, A., Mendoza, R., ... Lacasaña, M. (2016). Postnatal arsenic exposure and attention impairment in school children. Cortex, 74, 370-382. https://doi.org/10.1016/j.cortex.2014.12.018

Postnatal arsenic exposure and attention impairment in school children. / Rodríguez-Barranco, Miguel; Gil, Fernando; Hernández, Antonio F.; Alguacil, Juan; Lorca, Andres; Mendoza, Ramón; Gómez, Inmaculada; Molina-Villalba, Isabel; González-Alzaga, Beatriz; Aguilar-Garduño, Clemente; Rohlman, Diane; Lacasaña, Marina.

In: Cortex, Vol. 74, 01.01.2016, p. 370-382.

Research output: Contribution to journalArticle

Rodríguez-Barranco, M, Gil, F, Hernández, AF, Alguacil, J, Lorca, A, Mendoza, R, Gómez, I, Molina-Villalba, I, González-Alzaga, B, Aguilar-Garduño, C, Rohlman, D & Lacasaña, M 2016, 'Postnatal arsenic exposure and attention impairment in school children', Cortex, vol. 74, pp. 370-382. https://doi.org/10.1016/j.cortex.2014.12.018
Rodríguez-Barranco M, Gil F, Hernández AF, Alguacil J, Lorca A, Mendoza R et al. Postnatal arsenic exposure and attention impairment in school children. Cortex. 2016 Jan 1;74:370-382. https://doi.org/10.1016/j.cortex.2014.12.018
Rodríguez-Barranco, Miguel ; Gil, Fernando ; Hernández, Antonio F. ; Alguacil, Juan ; Lorca, Andres ; Mendoza, Ramón ; Gómez, Inmaculada ; Molina-Villalba, Isabel ; González-Alzaga, Beatriz ; Aguilar-Garduño, Clemente ; Rohlman, Diane ; Lacasaña, Marina. / Postnatal arsenic exposure and attention impairment in school children. In: Cortex. 2016 ; Vol. 74. pp. 370-382.
@article{2dc8e4a4d7ab4eeab993e36ee9367167,
title = "Postnatal arsenic exposure and attention impairment in school children",
abstract = "Over the last few decades there has been an increased concern about the health risks from exposure to metallic trace elements, including arsenic, because of their potential neurotoxic effects on the developing brain. This study assessed whether urinary arsenic (UA) levels are associated with attention performance and Attention-Deficit/Hyperactivity Disorder (ADHD) in children living in an area with high industrial and mining activities in Southwestern Spain. A cross-sectional study was conducted on 261 children aged 6-9 years. Arsenic levels were determined in urine samples. Attention was measured by using 4 independent tools: a) tests from the Behavioral Assessment and Research System (BARS) designed to measure attention function: Simple Reaction Time Test (RTT), Continuous Performance Test (CPT) and Selective Attention Test (SAT); b) AULA Test, a virtual reality (VR)-based test that evaluates children's response to several stimuli in an environment simulating a classroom; c) Child Behavior Checklist (CBCL), administered to parents; and d) Teacher's Report Form (TRF), administered to teachers. Multivariate linear and logistic regression models, adjusted for potential confounders, were used to estimate the magnitude of the association between UA levels and attention performance scores. Higher UA levels were associated with an increased latency of response in RTT (β = 12.3; 95{\%} confidence interval (CI): 3.5-21.1) and SAT (β = 3.6; 95{\%} CI: .4-6.8) as well as with worse performance on selective and focalized attention in the AULA test (β for impulsivity = .6; 95{\%} CI: .1-1.1; β for inattention = .5; 95{\%} CI: .03-1.0). A dose-response relationship was observed between UA levels and inattention and impulsivity scores. In contrast, results from the CBCL and TRF tests failed to show a significant association with UA levels. In conclusion, UA levels were associated with impaired attention/cognitive function, even at levels considered safe. These results provide additional evidence that postnatal arsenic exposure impairs neurological function in children.",
keywords = "ADHD, Arsenic, Attention, Children, Neurobehavioral disorder, Neurotoxicity",
author = "Miguel Rodr{\'i}guez-Barranco and Fernando Gil and Hern{\'a}ndez, {Antonio F.} and Juan Alguacil and Andres Lorca and Ram{\'o}n Mendoza and Inmaculada G{\'o}mez and Isabel Molina-Villalba and Beatriz Gonz{\'a}lez-Alzaga and Clemente Aguilar-Gardu{\~n}o and Diane Rohlman and Marina Lacasa{\~n}a",
year = "2016",
month = "1",
day = "1",
doi = "10.1016/j.cortex.2014.12.018",
language = "English (US)",
volume = "74",
pages = "370--382",
journal = "Cortex",
issn = "0010-9452",
publisher = "Masson SpA",

}

TY - JOUR

T1 - Postnatal arsenic exposure and attention impairment in school children

AU - Rodríguez-Barranco, Miguel

AU - Gil, Fernando

AU - Hernández, Antonio F.

AU - Alguacil, Juan

AU - Lorca, Andres

AU - Mendoza, Ramón

AU - Gómez, Inmaculada

AU - Molina-Villalba, Isabel

AU - González-Alzaga, Beatriz

AU - Aguilar-Garduño, Clemente

AU - Rohlman, Diane

AU - Lacasaña, Marina

PY - 2016/1/1

Y1 - 2016/1/1

N2 - Over the last few decades there has been an increased concern about the health risks from exposure to metallic trace elements, including arsenic, because of their potential neurotoxic effects on the developing brain. This study assessed whether urinary arsenic (UA) levels are associated with attention performance and Attention-Deficit/Hyperactivity Disorder (ADHD) in children living in an area with high industrial and mining activities in Southwestern Spain. A cross-sectional study was conducted on 261 children aged 6-9 years. Arsenic levels were determined in urine samples. Attention was measured by using 4 independent tools: a) tests from the Behavioral Assessment and Research System (BARS) designed to measure attention function: Simple Reaction Time Test (RTT), Continuous Performance Test (CPT) and Selective Attention Test (SAT); b) AULA Test, a virtual reality (VR)-based test that evaluates children's response to several stimuli in an environment simulating a classroom; c) Child Behavior Checklist (CBCL), administered to parents; and d) Teacher's Report Form (TRF), administered to teachers. Multivariate linear and logistic regression models, adjusted for potential confounders, were used to estimate the magnitude of the association between UA levels and attention performance scores. Higher UA levels were associated with an increased latency of response in RTT (β = 12.3; 95% confidence interval (CI): 3.5-21.1) and SAT (β = 3.6; 95% CI: .4-6.8) as well as with worse performance on selective and focalized attention in the AULA test (β for impulsivity = .6; 95% CI: .1-1.1; β for inattention = .5; 95% CI: .03-1.0). A dose-response relationship was observed between UA levels and inattention and impulsivity scores. In contrast, results from the CBCL and TRF tests failed to show a significant association with UA levels. In conclusion, UA levels were associated with impaired attention/cognitive function, even at levels considered safe. These results provide additional evidence that postnatal arsenic exposure impairs neurological function in children.

AB - Over the last few decades there has been an increased concern about the health risks from exposure to metallic trace elements, including arsenic, because of their potential neurotoxic effects on the developing brain. This study assessed whether urinary arsenic (UA) levels are associated with attention performance and Attention-Deficit/Hyperactivity Disorder (ADHD) in children living in an area with high industrial and mining activities in Southwestern Spain. A cross-sectional study was conducted on 261 children aged 6-9 years. Arsenic levels were determined in urine samples. Attention was measured by using 4 independent tools: a) tests from the Behavioral Assessment and Research System (BARS) designed to measure attention function: Simple Reaction Time Test (RTT), Continuous Performance Test (CPT) and Selective Attention Test (SAT); b) AULA Test, a virtual reality (VR)-based test that evaluates children's response to several stimuli in an environment simulating a classroom; c) Child Behavior Checklist (CBCL), administered to parents; and d) Teacher's Report Form (TRF), administered to teachers. Multivariate linear and logistic regression models, adjusted for potential confounders, were used to estimate the magnitude of the association between UA levels and attention performance scores. Higher UA levels were associated with an increased latency of response in RTT (β = 12.3; 95% confidence interval (CI): 3.5-21.1) and SAT (β = 3.6; 95% CI: .4-6.8) as well as with worse performance on selective and focalized attention in the AULA test (β for impulsivity = .6; 95% CI: .1-1.1; β for inattention = .5; 95% CI: .03-1.0). A dose-response relationship was observed between UA levels and inattention and impulsivity scores. In contrast, results from the CBCL and TRF tests failed to show a significant association with UA levels. In conclusion, UA levels were associated with impaired attention/cognitive function, even at levels considered safe. These results provide additional evidence that postnatal arsenic exposure impairs neurological function in children.

KW - ADHD

KW - Arsenic

KW - Attention

KW - Children

KW - Neurobehavioral disorder

KW - Neurotoxicity

UR - http://www.scopus.com/inward/record.url?scp=84956582323&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84956582323&partnerID=8YFLogxK

U2 - 10.1016/j.cortex.2014.12.018

DO - 10.1016/j.cortex.2014.12.018

M3 - Article

C2 - 25682472

AN - SCOPUS:84956582323

VL - 74

SP - 370

EP - 382

JO - Cortex

JF - Cortex

SN - 0010-9452

ER -