Postmenopausal hyperandrogenism caused by a benign cystic teratoma: A case report

Diana H. Wu, Daniel G. McMurtrie, Samuel D. Hirsch, Carolyn M. Johnston

Research output: Contribution to journalArticle

9 Scopus citations

Abstract

BACKGROUND: Mature, benign cystic teratomas of the ovary are common in reproductive-age women, but they are very rarely associated with androgen production and subsequent development of hirsutism or virilization. We describe a case of postmenopausal hirsutism and hyperandrogenism caused by a mature cystic teratoma as well as the 7 previously reported cases. CASE: A 55-year-old, postmenopausal woman presented with hirsutism and unilateral lower extremity edema. Pelvic ultrasound showed a complex cystic mass in the left ovary measuring 6.0 × 7.0 × 10 cm, and laboratory evaluations revealed progressively increasing testosterone levels. The patient underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy, with resection of a large, complex mass originating in the left ovary. The pathology department found 2 left, mature ovarian cystic teratomas containing a layer of Leydig cells. Postoperatively the patient experienced rapid normalization of the elevated testosterone level. CONCLUSION: Although rare, ovarian production of androgens resulting in hirsutism or virilization can occur with a hormonally active mature cystic teratoma.

Original languageEnglish (US)
Pages (from-to)141-144
Number of pages4
JournalJournal of Reproductive Medicine for the Obstetrician and Gynecologist
Volume53
Issue number2
StatePublished - Feb 1 2008

Keywords

  • Cystic
  • Hyperandrogenism
  • Mature
  • Postmenopause
  • Teratoma
  • Testosterone

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynecology

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