Postintensive Care Syndrome in Pediatric Critical Care Survivors: Therapeutic Options to Improve Outcomes After Acquired Brain Injury

Cydni N. Williams, Mary E. Hartman, Kristin P. Guilliams, Rejean M. Guerriero, Juan A. Piantino, Christopher C. Bosworth, Skyler S. Leonard, Kathryn Bradbury, Amanda Wagner, Trevor A. Hall

Research output: Contribution to journalReview article


Purpose of review: Children surviving the pediatric intensive care unit (PICU) with neurologic illness or injury have long-term morbidities in physical, cognitive, emotional, and social functioning termed postintensive care syndrome (PICS). In this article, we review acute and longitudinal management strategies available to combat PICS in children with acquired brain injury. Recent findings: Few intervention studies in this vulnerable population target PICS morbidities. Small studies show promise for both inpatient- and outpatient-initiated therapies, mainly focusing on a single domain of PICS and evaluating heterogeneous populations. While evaluating the effects of interventions on longitudinal PICS outcomes is in its infancy, longitudinal clinical programs targeting PICS are increasing. A multidisciplinary team with inpatient and outpatient presence is necessary to deliver the holistic integrated care required to address all domains of PICS in patients and families. Summary: While PICS is increasingly recognized as a chronic problem in PICU survivors with acquired brain injury, few interventions have targeted PICS morbidities. Research is needed to improve physical, cognitive, emotional, and social outcomes in survivors and their families.

Original languageEnglish (US)
Article number49
JournalCurrent Treatment Options in Neurology
Issue number10
StatePublished - Oct 1 2019



  • Brain injury
  • Critical care
  • Outcomes
  • Pediatric
  • Stroke

ASJC Scopus subject areas

  • Clinical Neurology

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