Post-operative radiation therapy for advanced-stage oropharyngeal cancer

Eric Hansen, Kathryn Panwala, John Holland

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Between 1985 and 1999, 43 patients with locally-advanced, resectable oropharyngeal cancer were treated with combined surgery and post-operative radiation therapy (RT) at Oregon Health and Science University. Five patients (12 per cent) had Stage III disease and 38 patients (88 per cent) had Stage IV disease. All patients had gross total resections of the primary tumour. Thirty-seven patients had neck dissections for regional disease. RT consisted of a mean tumour-bed dose of 63.0 Gy delivered in 1.8-2.0 Gy fractions over a mean of 49 days. At three- and five-years, the actuarial local control was 96 per cent and the actuarial local/regional control was 80 per cent. The three- and five-year actuarial rates of distant metastases were 41 per cent and 46 per cent, respectively. The actuarial overall survival at three- and five-years was 41 per cent and 34 per cent, respectively. The actuarial rates of progression-free survival were 49 per cent at three-years and 45 per cent at five years. Combined surgery and post-operative RT for advanced-stage oropharyngeal cancer results in excellent local/regional control. This particular group of patients experienced a high-rate of developing distant metastases.

Original languageEnglish (US)
Pages (from-to)920-924
Number of pages5
JournalJournal of Laryngology and Otology
Volume116
Issue number11
DOIs
StatePublished - Nov 1 2002

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Oropharyngeal Neoplasms
Radiotherapy
Neoplasm Metastasis
Neck Dissection
Disease-Free Survival
Neoplasms
Survival
Health

Keywords

  • Oropharyngeal Neoplasms
  • Radiotherapy
  • Surgery

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Post-operative radiation therapy for advanced-stage oropharyngeal cancer. / Hansen, Eric; Panwala, Kathryn; Holland, John.

In: Journal of Laryngology and Otology, Vol. 116, No. 11, 01.11.2002, p. 920-924.

Research output: Contribution to journalArticle

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