Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema

T. Bragadeesh, A. R. Jayaweera, M. Pascotto, A. Micari, Dai-Trang (Elizabeth) Le, C. M. Kramer, F. H. Epstein, Sanjiv Kaul

    Research output: Contribution to journalArticle

    46 Citations (Scopus)

    Abstract

    Objective: To test the hypothesis that myocardial stunning is due to myofibrillar oedema. Methods: Experiments were performed in anaesthetised closed-chest pigs. In 15 pigs (group 1), myocardial stunning was produced by repetitive ischaemia and reperfusion; 5 pigs each were studied at 2 hours, 2 days, and 5 days later. Circumferential left ventricular (LV) midwall myocardial strain (Ecc) was estimated in vivo using tagged magnetic resonance imaging. Myocardial water content (MWC) was measured post mortem, from which interfilament lattice distance (d) was calculated. In 6 pigs (group 2), myocardial dysfunction was produced by intracoronary administration of a mast cell degranulator. Animals were euthanised immediately upon induction of regional LV dysfunction to avoid development of inflammation. In 4 pigs (group 3), transmission electron microscopy (EM) was performed to quantify d in stunned versus normal myocardium. Results: In group 1 pigs, MWC was raised in the stunned compared with normal myocardium (pcc and MWC in the stunned myocardium (r = -0.81) and between Ecc and d (r = -0.90). A similar relation was noted between wall thickening and increase in MWC in group 2 (r = -0.84) pigs. In group 3 pigs, d on EM was significantly lower (40 (3) nmol/l) in normal myocardium than in stunned myocardium (46.4 (4) nmol/l), p

    Original languageEnglish (US)
    Pages (from-to)166-171
    Number of pages6
    JournalHeart
    Volume94
    Issue number2
    DOIs
    StatePublished - Feb 2008

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    Myocardial Stunning
    Edema
    Swine
    Myocardium
    Water
    Left Ventricular Dysfunction
    Transmission Electron Microscopy
    Mast Cells
    Reperfusion
    Electron Microscopy
    Thorax
    Ischemia
    Magnetic Resonance Imaging
    Inflammation

    ASJC Scopus subject areas

    • Cardiology and Cardiovascular Medicine
    • Medicine(all)

    Cite this

    Bragadeesh, T., Jayaweera, A. R., Pascotto, M., Micari, A., Le, D-T. E., Kramer, C. M., ... Kaul, S. (2008). Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema. Heart, 94(2), 166-171. https://doi.org/10.1136/hrt.2006.102434

    Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema. / Bragadeesh, T.; Jayaweera, A. R.; Pascotto, M.; Micari, A.; Le, Dai-Trang (Elizabeth); Kramer, C. M.; Epstein, F. H.; Kaul, Sanjiv.

    In: Heart, Vol. 94, No. 2, 02.2008, p. 166-171.

    Research output: Contribution to journalArticle

    Bragadeesh, T, Jayaweera, AR, Pascotto, M, Micari, A, Le, D-TE, Kramer, CM, Epstein, FH & Kaul, S 2008, 'Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema', Heart, vol. 94, no. 2, pp. 166-171. https://doi.org/10.1136/hrt.2006.102434
    Bragadeesh T, Jayaweera AR, Pascotto M, Micari A, Le D-TE, Kramer CM et al. Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema. Heart. 2008 Feb;94(2):166-171. https://doi.org/10.1136/hrt.2006.102434
    Bragadeesh, T. ; Jayaweera, A. R. ; Pascotto, M. ; Micari, A. ; Le, Dai-Trang (Elizabeth) ; Kramer, C. M. ; Epstein, F. H. ; Kaul, Sanjiv. / Post-ischaemic myocardial dysfunction (stunning) results from myofibrillar oedema. In: Heart. 2008 ; Vol. 94, No. 2. pp. 166-171.
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    AU - Le, Dai-Trang (Elizabeth)

    AU - Kramer, C. M.

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