Abstract
AUTOIMMUNE mechanisms may play a major role in several human demyelinating diseases1. Myelin contains components, principally a basic class of protein, which, when injected systemically with an adjuvant, elicit in the experimental animal a demyelinating encephalomyelitis or neuritis with perivascular infiltration of lymphocytes and inflammatory cells1,2. A satisfactory hypothesis is that the potential self-antigens are secluded from the immune systems in the normal living animal3. Evidence for such a specific compartmentation of myelin components, however, has been lacking up to now. This has led several authors to suggest alternative explanations 1,4,5. Here we demonstrate the structural basis for a seclusion mechanism within both peripheral and central myelin sheaths in different animal species.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 725-727 |
| Number of pages | 3 |
| Journal | Nature |
| Volume | 251 |
| Issue number | 5477 |
| DOIs | |
| State | Published - 1974 |
| Externally published | Yes |
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Cite this
Possible role of zonula occludens of the myelin sheath in demyelinating conditions. / Mugnaini, Enrico; Schnapp, Bruce.
In: Nature, Vol. 251, No. 5477, 1974, p. 725-727.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Possible role of zonula occludens of the myelin sheath in demyelinating conditions
AU - Mugnaini, Enrico
AU - Schnapp, Bruce
PY - 1974
Y1 - 1974
N2 - AUTOIMMUNE mechanisms may play a major role in several human demyelinating diseases1. Myelin contains components, principally a basic class of protein, which, when injected systemically with an adjuvant, elicit in the experimental animal a demyelinating encephalomyelitis or neuritis with perivascular infiltration of lymphocytes and inflammatory cells1,2. A satisfactory hypothesis is that the potential self-antigens are secluded from the immune systems in the normal living animal3. Evidence for such a specific compartmentation of myelin components, however, has been lacking up to now. This has led several authors to suggest alternative explanations 1,4,5. Here we demonstrate the structural basis for a seclusion mechanism within both peripheral and central myelin sheaths in different animal species.
AB - AUTOIMMUNE mechanisms may play a major role in several human demyelinating diseases1. Myelin contains components, principally a basic class of protein, which, when injected systemically with an adjuvant, elicit in the experimental animal a demyelinating encephalomyelitis or neuritis with perivascular infiltration of lymphocytes and inflammatory cells1,2. A satisfactory hypothesis is that the potential self-antigens are secluded from the immune systems in the normal living animal3. Evidence for such a specific compartmentation of myelin components, however, has been lacking up to now. This has led several authors to suggest alternative explanations 1,4,5. Here we demonstrate the structural basis for a seclusion mechanism within both peripheral and central myelin sheaths in different animal species.
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UR - http://www.scopus.com/inward/citedby.url?scp=0016312806&partnerID=8YFLogxK
U2 - 10.1038/251725a0
DO - 10.1038/251725a0
M3 - Article
VL - 251
SP - 725
EP - 727
JO - Nature
JF - Nature
SN - 0028-0836
IS - 5477
ER -