Possible interrelationship between vitamins E and B12 in the disturbance in methylmalonate metabolism in vitamin E deficiency

A. S. Pappu, P. Fatterpaker, A. Sreenivasan

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

The disturbance in 2-methylmalonate metabolism resulting in its increased urinary excretion observed in vitamin E deficiency is not caused by increased formation of methylmalonate from propionate as is evident from the activity of the enzyme propionyl-CoA carboxylase (EC 6.4.1.3), but can be traced to an impairment in the conversion of methylmalonate into succinate by the vitamin B12-requiring enzyme, methylmalonyl-CoA mutase (EC 5.4.99.2) in rat liver. It is shown that the decrease in the activity of methylmalonyl-CoA mutase in vitamin E deficiency is not a consequence of a secondary vitamin B12 deficiency. Peroxidative destruction of the coenzyme in vitamin E deficiency was also ruled out. The results suggest a defect in the conversion of cyanocobalamin into its coenzyme form.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalBiochemical Journal
Volume172
Issue number1
DOIs
StatePublished - Jan 1 1978

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Cell Biology

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