Possible interrelationship between vitamins E and B12 in the disturbance in methylmalonate metabolism in vitamin E deficiency

Anuradha Pappu, P. Fatterpaker, A. Sreenivasan

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

The disturbance in 2-methylmalonate metabolism resulting in its increased urinary excretion observed in vitamin E deficiency is not caused by increased formation of methylmalonate from propionate as is evident from the activity of the enzyme propionyl-CoA carboxylase (EC 6.4.1.3), but can be traced to an impairment in the conversion of methylmalonate into succinate by the vitamin B12-requiring enzyme, methylmalonyl-CoA mutase (EC 5.4.99.2) in rat liver. It is shown that the decrease in the activity of methylmalonyl-CoA mutase in vitamin E deficiency is not a consequence of a secondary vitamin B12 deficiency. Peroxidative destruction of the coenzyme in vitamin E deficiency was also ruled out. The results suggest a defect in the conversion of cyanocobalamin into its coenzyme form.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalBiochemical Journal
Volume172
Issue number1
StatePublished - 1978
Externally publishedYes

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Methylmalonyl-CoA Mutase
Vitamin E Deficiency
Vitamin B 12
Vitamin E
Metabolism
Coenzymes
propionyl CoA carboxylase (ATP-hydrolyzing)
Methylmalonyl-CoA Decarboxylase
Vitamin B 12 Deficiency
Propionates
Succinic Acid
Enzymes
Liver
Rats
Defects

ASJC Scopus subject areas

  • Biochemistry

Cite this

Possible interrelationship between vitamins E and B12 in the disturbance in methylmalonate metabolism in vitamin E deficiency. / Pappu, Anuradha; Fatterpaker, P.; Sreenivasan, A.

In: Biochemical Journal, Vol. 172, No. 1, 1978, p. 115-121.

Research output: Contribution to journalArticle

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