Possible interrelationship between vitamins E and B12 in the disturbance in methylmalonate metabolism in vitamin E deficiency

Anuradha Pappu, P. Fatterpaker, A. Sreenivasan

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The disturbance in 2-methylmalonate metabolism resulting in its increased urinary excretion observed in vitamin E deficiency is not caused by increased formation of methylmalonate from propionate as is evident from the activity of the enzyme propionyl-CoA carboxylase (EC, but can be traced to an impairment in the conversion of methylmalonate into succinate by the vitamin B12-requiring enzyme, methylmalonyl-CoA mutase (EC in rat liver. It is shown that the decrease in the activity of methylmalonyl-CoA mutase in vitamin E deficiency is not a consequence of a secondary vitamin B12 deficiency. Peroxidative destruction of the coenzyme in vitamin E deficiency was also ruled out. The results suggest a defect in the conversion of cyanocobalamin into its coenzyme form.

Original languageEnglish (US)
Pages (from-to)115-121
Number of pages7
JournalBiochemical Journal
Issue number1
Publication statusPublished - 1978
Externally publishedYes


ASJC Scopus subject areas

  • Biochemistry

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