Porcine cysticercosis

Possible cross-reactivity of taenia hydatigena to GP50 antigen in the enzyme-linked immunoelectrotransfer blot assay

Claudio Muro, Luis A. Gomez-Puerta, Robert H. Flecker, Ricardo Gamboa, Percy Vilchez Barreto, Pierre Dorny, Victor C.W. Tsang, Robert H. Gilman, Armando E. Gonzalez, Hector H. Garcia, Seth O'Neal

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The lentil lectin glycoprotein enzyme-linked immunoelectrotransfer blot (LLGP EITB, reported sensitivity 99% and specificity 100%) is used as a serologic marker of exposure to Taenia solium in pigs. However, only a limited number of parasites have been evaluated for cross reactivity. Pigs may host other related cestode infections, including Taenia hydatigena, which have not been formally evaluated for cross-reactions.Weinvestigated a corral in Tumbes, Peru, a region where a cysticercosis elimination demonstration project was completed in 2012. In this corral, 14/19 (73.7%) 6-8-week-old piglets were reactive to GP50 on LLGP EITB, and all had circulating Taenia sp. antigens. From eight necropsied piglets; four were infected with T. hydatigenametacestodes whereas none had evidence of T. solium infection. Two resident dogs were subsequently confirmed to have T. hydatigena taeniasis. These results suggest GP50 crossreactivity in T. hydatigena-infected pigs, although controlled experimental infection is needed to confirm this hypothesis.

Original languageEnglish (US)
Pages (from-to)1830-1832
Number of pages3
JournalAmerican Journal of Tropical Medicine and Hygiene
Volume97
Issue number6
DOIs
StatePublished - Jan 1 2017

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Taenia
Cysticercosis
Taeniasis
Taenia solium
Swine
Antigens
Enzymes
Cestode Infections
Peru
Cross Reactions
Glycoproteins
Parasites
Dogs
Sensitivity and Specificity
Infection
brain synaptic membrane glycoprotein gp 50

ASJC Scopus subject areas

  • Parasitology
  • Infectious Diseases
  • Virology

Cite this

Porcine cysticercosis : Possible cross-reactivity of taenia hydatigena to GP50 antigen in the enzyme-linked immunoelectrotransfer blot assay. / Muro, Claudio; Gomez-Puerta, Luis A.; Flecker, Robert H.; Gamboa, Ricardo; Barreto, Percy Vilchez; Dorny, Pierre; Tsang, Victor C.W.; Gilman, Robert H.; Gonzalez, Armando E.; Garcia, Hector H.; O'Neal, Seth.

In: American Journal of Tropical Medicine and Hygiene, Vol. 97, No. 6, 01.01.2017, p. 1830-1832.

Research output: Contribution to journalArticle

Muro, C, Gomez-Puerta, LA, Flecker, RH, Gamboa, R, Barreto, PV, Dorny, P, Tsang, VCW, Gilman, RH, Gonzalez, AE, Garcia, HH & O'Neal, S 2017, 'Porcine cysticercosis: Possible cross-reactivity of taenia hydatigena to GP50 antigen in the enzyme-linked immunoelectrotransfer blot assay', American Journal of Tropical Medicine and Hygiene, vol. 97, no. 6, pp. 1830-1832. https://doi.org/10.4269/ajtmh.17-0378
Muro, Claudio ; Gomez-Puerta, Luis A. ; Flecker, Robert H. ; Gamboa, Ricardo ; Barreto, Percy Vilchez ; Dorny, Pierre ; Tsang, Victor C.W. ; Gilman, Robert H. ; Gonzalez, Armando E. ; Garcia, Hector H. ; O'Neal, Seth. / Porcine cysticercosis : Possible cross-reactivity of taenia hydatigena to GP50 antigen in the enzyme-linked immunoelectrotransfer blot assay. In: American Journal of Tropical Medicine and Hygiene. 2017 ; Vol. 97, No. 6. pp. 1830-1832.
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