TY - JOUR
T1 - Population-based assessment of non-melanoma cancer risk in relatives of cutaneous melanoma probands
AU - Larson, April A.
AU - Leachman, Sancy A.
AU - Eliason, Mark J.
AU - Cannon-Albright, Lisa A.
N1 - Funding Information:
Funding was provided by National Institutes of Health National Cancer Institute Grant R01 CA102422 (to L.A.C.A.); the Tom C. Mathews, Jr Familial Melanoma Research Clinic; the Huntsman Cancer Foundation; and the Multidisciplinary Cancer Research Training Program (to A.A.L.). Research was supported by the Utah Cancer Registry, which is funded by Contract No. N01-PC-35141 from the National Cancer Institute's Surveillance, Epidemiology, and End Results Program with additional support from the Utah State Department of Heath and the University of Utah. Partial support for all data sets within the UPDB was provided by the University of Utah Huntsman Cancer Institute. These results were presented in part, in oral and abstract form, at the 64th Annual Meeting of the Society of Investigative Dermatology meeting, Miami, Florida, May 2003.
PY - 2007/1/27
Y1 - 2007/1/27
N2 - Using the unique Utah Population Database, which links Utah genealogical data with Utah cancer data, we examined risks for other cancers among relatives of 4,079 melanoma cases. Age- and sex-specific rates for 35 different cancer sites were calculated, and used to estimate relative risks among relatives. In addition to the well-recognized risk for melanoma among first-degree relatives, we found significantly increased risks for prostate, breast, and colon cancers, non-Hodgkin's lymphoma, and multiple myeloma, ranging from 32 to 72% increased risk. Among second-degree relatives, in addition to increased risk for melanoma, we identified significantly increased risks for prostate cancer and multiple myeloma (27 and 53% increase, respectively). Among first-degree relatives of melanoma cases diagnosed before the age of 40 years, we found significantly elevated risks for cutaneous melanoma (380% increase) and prostate cancer (83% increase). Significantly increased risks for prostate cancer and multiple myeloma in both first- and second-degree relatives of melanoma cases are suggestive of heritable cancer syndromes. The increased risks for five additional cancer types in first-degree relatives of melanoma cases suggest that individuals with a family history of melanoma should strictly adhere to recommended screenings for all cancers.
AB - Using the unique Utah Population Database, which links Utah genealogical data with Utah cancer data, we examined risks for other cancers among relatives of 4,079 melanoma cases. Age- and sex-specific rates for 35 different cancer sites were calculated, and used to estimate relative risks among relatives. In addition to the well-recognized risk for melanoma among first-degree relatives, we found significantly increased risks for prostate, breast, and colon cancers, non-Hodgkin's lymphoma, and multiple myeloma, ranging from 32 to 72% increased risk. Among second-degree relatives, in addition to increased risk for melanoma, we identified significantly increased risks for prostate cancer and multiple myeloma (27 and 53% increase, respectively). Among first-degree relatives of melanoma cases diagnosed before the age of 40 years, we found significantly elevated risks for cutaneous melanoma (380% increase) and prostate cancer (83% increase). Significantly increased risks for prostate cancer and multiple myeloma in both first- and second-degree relatives of melanoma cases are suggestive of heritable cancer syndromes. The increased risks for five additional cancer types in first-degree relatives of melanoma cases suggest that individuals with a family history of melanoma should strictly adhere to recommended screenings for all cancers.
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U2 - 10.1038/sj.jid.5700507
DO - 10.1038/sj.jid.5700507
M3 - Article
C2 - 16902418
AN - SCOPUS:33845734043
SN - 0022-202X
VL - 127
SP - 183
EP - 188
JO - Journal of Investigative Dermatology
JF - Journal of Investigative Dermatology
IS - 1
ER -