Population-based analysis of prognostic factors and survival in familial melanoma

Scott R. Florell, Kenneth M. Boucher, Gilda Garibotti, John Astle, Richard Kerber, Geraldine Mineau, Charles Wiggins, R. Dirk Noyes, Alexander Tsodikov, Lisa A. Cannon-Albright, John J. Zone, Wolfram E. Samlowski, Sancy Leachman

Research output: Contribution to journalArticle

67 Citations (Scopus)

Abstract

Purpose: Familial melanoma patients are reported to present with thinner melanomas, to be younger at the time of diagnosis, and to have a greater likelihood of developing multiple primary tumors. We sought to determine whether melanomas that occur in a familial setting demonstrate different prognostic and survival statistics relative to sporadic melanoma. Patients and Methods: This population-based study used the Utah Cancer Registry and Utah Population Database to objectively evaluate prognostic and survival statistics of the familial melanoma population. From 1973 to 1999, there were 7,785 cases of invasive melanoma identified through the Utah Cancer Registry. These were linked to the Utah Population Database, resulting in 2,659 subjects with family-history information from which a familiality score could be calculated. Cases scored in the top ninth percentile were assigned as high familial risk, and the remaining 91% were considered low familial risk. Results: Multivariate logistic-regression analysis found no association between sex, Breslow depth, Clark level, or survival and the familial status. Age at first diagnosis of invasive melanoma was slightly lower in the high-familial-risk group (57 v 60 years; P = .03). High-familial-risk subjects had more melanomas diagnosed at age 30 or younger (12% v 6%; P <.001). A significant difference in the overall number of individuals with two or more primary malignant melanomas was not detected among the groups (P = .2). Conclusion: These data suggest that melanomas occurring in the context of an underlying inherited susceptibility do not have a significantly different biologic behavior.

Original languageEnglish (US)
Pages (from-to)7168-7177
Number of pages10
JournalJournal of Clinical Oncology
Volume23
Issue number28
DOIs
StatePublished - 2005
Externally publishedYes

Fingerprint

Survival Analysis
Melanoma
Population
Survival
Registries
Databases
Neoplasms
Cutaneous Malignant Melanoma
Logistic Models
History
Regression Analysis

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Florell, S. R., Boucher, K. M., Garibotti, G., Astle, J., Kerber, R., Mineau, G., ... Leachman, S. (2005). Population-based analysis of prognostic factors and survival in familial melanoma. Journal of Clinical Oncology, 23(28), 7168-7177. https://doi.org/10.1200/JCO.2005.11.999

Population-based analysis of prognostic factors and survival in familial melanoma. / Florell, Scott R.; Boucher, Kenneth M.; Garibotti, Gilda; Astle, John; Kerber, Richard; Mineau, Geraldine; Wiggins, Charles; Noyes, R. Dirk; Tsodikov, Alexander; Cannon-Albright, Lisa A.; Zone, John J.; Samlowski, Wolfram E.; Leachman, Sancy.

In: Journal of Clinical Oncology, Vol. 23, No. 28, 2005, p. 7168-7177.

Research output: Contribution to journalArticle

Florell, SR, Boucher, KM, Garibotti, G, Astle, J, Kerber, R, Mineau, G, Wiggins, C, Noyes, RD, Tsodikov, A, Cannon-Albright, LA, Zone, JJ, Samlowski, WE & Leachman, S 2005, 'Population-based analysis of prognostic factors and survival in familial melanoma', Journal of Clinical Oncology, vol. 23, no. 28, pp. 7168-7177. https://doi.org/10.1200/JCO.2005.11.999
Florell SR, Boucher KM, Garibotti G, Astle J, Kerber R, Mineau G et al. Population-based analysis of prognostic factors and survival in familial melanoma. Journal of Clinical Oncology. 2005;23(28):7168-7177. https://doi.org/10.1200/JCO.2005.11.999
Florell, Scott R. ; Boucher, Kenneth M. ; Garibotti, Gilda ; Astle, John ; Kerber, Richard ; Mineau, Geraldine ; Wiggins, Charles ; Noyes, R. Dirk ; Tsodikov, Alexander ; Cannon-Albright, Lisa A. ; Zone, John J. ; Samlowski, Wolfram E. ; Leachman, Sancy. / Population-based analysis of prognostic factors and survival in familial melanoma. In: Journal of Clinical Oncology. 2005 ; Vol. 23, No. 28. pp. 7168-7177.
@article{1656b2a3aa93459bbd30623315835ff0,
title = "Population-based analysis of prognostic factors and survival in familial melanoma",
abstract = "Purpose: Familial melanoma patients are reported to present with thinner melanomas, to be younger at the time of diagnosis, and to have a greater likelihood of developing multiple primary tumors. We sought to determine whether melanomas that occur in a familial setting demonstrate different prognostic and survival statistics relative to sporadic melanoma. Patients and Methods: This population-based study used the Utah Cancer Registry and Utah Population Database to objectively evaluate prognostic and survival statistics of the familial melanoma population. From 1973 to 1999, there were 7,785 cases of invasive melanoma identified through the Utah Cancer Registry. These were linked to the Utah Population Database, resulting in 2,659 subjects with family-history information from which a familiality score could be calculated. Cases scored in the top ninth percentile were assigned as high familial risk, and the remaining 91{\%} were considered low familial risk. Results: Multivariate logistic-regression analysis found no association between sex, Breslow depth, Clark level, or survival and the familial status. Age at first diagnosis of invasive melanoma was slightly lower in the high-familial-risk group (57 v 60 years; P = .03). High-familial-risk subjects had more melanomas diagnosed at age 30 or younger (12{\%} v 6{\%}; P <.001). A significant difference in the overall number of individuals with two or more primary malignant melanomas was not detected among the groups (P = .2). Conclusion: These data suggest that melanomas occurring in the context of an underlying inherited susceptibility do not have a significantly different biologic behavior.",
author = "Florell, {Scott R.} and Boucher, {Kenneth M.} and Gilda Garibotti and John Astle and Richard Kerber and Geraldine Mineau and Charles Wiggins and Noyes, {R. Dirk} and Alexander Tsodikov and Cannon-Albright, {Lisa A.} and Zone, {John J.} and Samlowski, {Wolfram E.} and Sancy Leachman",
year = "2005",
doi = "10.1200/JCO.2005.11.999",
language = "English (US)",
volume = "23",
pages = "7168--7177",
journal = "Journal of Clinical Oncology",
issn = "0732-183X",
publisher = "American Society of Clinical Oncology",
number = "28",

}

TY - JOUR

T1 - Population-based analysis of prognostic factors and survival in familial melanoma

AU - Florell, Scott R.

AU - Boucher, Kenneth M.

AU - Garibotti, Gilda

AU - Astle, John

AU - Kerber, Richard

AU - Mineau, Geraldine

AU - Wiggins, Charles

AU - Noyes, R. Dirk

AU - Tsodikov, Alexander

AU - Cannon-Albright, Lisa A.

AU - Zone, John J.

AU - Samlowski, Wolfram E.

AU - Leachman, Sancy

PY - 2005

Y1 - 2005

N2 - Purpose: Familial melanoma patients are reported to present with thinner melanomas, to be younger at the time of diagnosis, and to have a greater likelihood of developing multiple primary tumors. We sought to determine whether melanomas that occur in a familial setting demonstrate different prognostic and survival statistics relative to sporadic melanoma. Patients and Methods: This population-based study used the Utah Cancer Registry and Utah Population Database to objectively evaluate prognostic and survival statistics of the familial melanoma population. From 1973 to 1999, there were 7,785 cases of invasive melanoma identified through the Utah Cancer Registry. These were linked to the Utah Population Database, resulting in 2,659 subjects with family-history information from which a familiality score could be calculated. Cases scored in the top ninth percentile were assigned as high familial risk, and the remaining 91% were considered low familial risk. Results: Multivariate logistic-regression analysis found no association between sex, Breslow depth, Clark level, or survival and the familial status. Age at first diagnosis of invasive melanoma was slightly lower in the high-familial-risk group (57 v 60 years; P = .03). High-familial-risk subjects had more melanomas diagnosed at age 30 or younger (12% v 6%; P <.001). A significant difference in the overall number of individuals with two or more primary malignant melanomas was not detected among the groups (P = .2). Conclusion: These data suggest that melanomas occurring in the context of an underlying inherited susceptibility do not have a significantly different biologic behavior.

AB - Purpose: Familial melanoma patients are reported to present with thinner melanomas, to be younger at the time of diagnosis, and to have a greater likelihood of developing multiple primary tumors. We sought to determine whether melanomas that occur in a familial setting demonstrate different prognostic and survival statistics relative to sporadic melanoma. Patients and Methods: This population-based study used the Utah Cancer Registry and Utah Population Database to objectively evaluate prognostic and survival statistics of the familial melanoma population. From 1973 to 1999, there were 7,785 cases of invasive melanoma identified through the Utah Cancer Registry. These were linked to the Utah Population Database, resulting in 2,659 subjects with family-history information from which a familiality score could be calculated. Cases scored in the top ninth percentile were assigned as high familial risk, and the remaining 91% were considered low familial risk. Results: Multivariate logistic-regression analysis found no association between sex, Breslow depth, Clark level, or survival and the familial status. Age at first diagnosis of invasive melanoma was slightly lower in the high-familial-risk group (57 v 60 years; P = .03). High-familial-risk subjects had more melanomas diagnosed at age 30 or younger (12% v 6%; P <.001). A significant difference in the overall number of individuals with two or more primary malignant melanomas was not detected among the groups (P = .2). Conclusion: These data suggest that melanomas occurring in the context of an underlying inherited susceptibility do not have a significantly different biologic behavior.

UR - http://www.scopus.com/inward/record.url?scp=27244435224&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=27244435224&partnerID=8YFLogxK

U2 - 10.1200/JCO.2005.11.999

DO - 10.1200/JCO.2005.11.999

M3 - Article

C2 - 16192601

AN - SCOPUS:27244435224

VL - 23

SP - 7168

EP - 7177

JO - Journal of Clinical Oncology

JF - Journal of Clinical Oncology

SN - 0732-183X

IS - 28

ER -