Abstract
Purpose: To evaluate differences in key outcomes between younger and older women receiving the oral contraceptive oestradiol valerate/dienogest (E2V/DNG). Methods: We conducted a pooled post hoc analysis of primary data from 12 studies of E2V/DNG, stratified by age (≤25 [n = 1309] and >25 [n = 2132] years). Outcomes included safety, efficacy, bleeding profile and hormone-withdrawal-associated symptoms (HWAS). Bleeding and HWAS analyses are also presented for women aged ≤20 years (n = 362). Discontinuations were considered a proxy for patient satisfaction. Results: Results were generally similar for younger and older women. The percentage of women aged ≤25 and >25 years experiencing intracyclic bleeding did not differ between groups (13.4% and 12.8% at cycle 12, respectively), with similar results in women aged ≤20 years (12.7%, cycle 12). Rates of withdrawal bleeding were very similar in women aged ≤25 and >25 years (78.5% and 78.9%, respectively, cycle 12). We also found a similar adjusted Pearl index in the two age groups (0.45 vs 0.57, respectively), similar rates of AEs and HWAS and no difference in discontinuations. Conclusions: Women aged ≤25 and >25 years have a similar experience with an E2V/DNV oral contraceptive, supporting this as an appropriate contraceptive option in younger and older women.
Original language | English (US) |
---|---|
Pages (from-to) | 98-105 |
Number of pages | 8 |
Journal | European Journal of Contraception and Reproductive Health Care |
Volume | 25 |
Issue number | 2 |
DOIs | |
State | Published - Mar 3 2020 |
Keywords
- Oral contraceptive
- bleeding
- dienogest
- hormone-withdrawal-associated symptoms
- oestradiol valerate
- safety
- young women
ASJC Scopus subject areas
- Reproductive Medicine
- Obstetrics and Gynecology
- Pharmacology (medical)