Pontine lesions produce apneusis in the rat

Shaun Morrison, S. L. Cravo, H. M. Wilfehrt

Research output: Contribution to journalArticle

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Abstract

Although lesion experiments in the vagotomized cat have indicated that neurons in the parabrachial region of the dorsolateral pons contribute to the mechanisms involved in terminating inspiration, a similar role for pontine structures in the rat has been questioned since pontomedullary transections in the anesthetized rat failed to prolong inspiration. In the present study, lesions of the parabrachial pons of the decerebrate, unanesthetized rat produced an increase in the duration of inspiration to 400% of control and a doubling of the duration of expiration, suggesting a role for this pontine area in the regulation of the timing of the phases of respiration.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalBrain Research
Volume652
Issue number1
DOIs
Publication statusPublished - Jul 25 1994
Externally publishedYes

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Keywords

  • Decerebration
  • Inspiratory duration
  • Parabrachial complex
  • Phrenic nerve
  • Pons
  • Respiratory timing

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

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