Pontine lesions produce apneusis in the rat

Shaun Morrison, S. L. Cravo, H. M. Wilfehrt

Research output: Contribution to journalArticle

42 Citations (Scopus)

Abstract

Although lesion experiments in the vagotomized cat have indicated that neurons in the parabrachial region of the dorsolateral pons contribute to the mechanisms involved in terminating inspiration, a similar role for pontine structures in the rat has been questioned since pontomedullary transections in the anesthetized rat failed to prolong inspiration. In the present study, lesions of the parabrachial pons of the decerebrate, unanesthetized rat produced an increase in the duration of inspiration to 400% of control and a doubling of the duration of expiration, suggesting a role for this pontine area in the regulation of the timing of the phases of respiration.

Original languageEnglish (US)
Pages (from-to)83-86
Number of pages4
JournalBrain Research
Volume652
Issue number1
DOIs
StatePublished - Jul 25 1994
Externally publishedYes

Fingerprint

Pons
Respiration
Cats
Neurons

Keywords

  • Decerebration
  • Inspiratory duration
  • Parabrachial complex
  • Phrenic nerve
  • Pons
  • Respiratory timing

ASJC Scopus subject areas

  • Developmental Biology
  • Molecular Biology
  • Clinical Neurology
  • Neuroscience(all)

Cite this

Pontine lesions produce apneusis in the rat. / Morrison, Shaun; Cravo, S. L.; Wilfehrt, H. M.

In: Brain Research, Vol. 652, No. 1, 25.07.1994, p. 83-86.

Research output: Contribution to journalArticle

Morrison, Shaun ; Cravo, S. L. ; Wilfehrt, H. M. / Pontine lesions produce apneusis in the rat. In: Brain Research. 1994 ; Vol. 652, No. 1. pp. 83-86.
@article{3bfaa21d75584fd8a0e57982eb161af2,
title = "Pontine lesions produce apneusis in the rat",
abstract = "Although lesion experiments in the vagotomized cat have indicated that neurons in the parabrachial region of the dorsolateral pons contribute to the mechanisms involved in terminating inspiration, a similar role for pontine structures in the rat has been questioned since pontomedullary transections in the anesthetized rat failed to prolong inspiration. In the present study, lesions of the parabrachial pons of the decerebrate, unanesthetized rat produced an increase in the duration of inspiration to 400{\%} of control and a doubling of the duration of expiration, suggesting a role for this pontine area in the regulation of the timing of the phases of respiration.",
keywords = "Decerebration, Inspiratory duration, Parabrachial complex, Phrenic nerve, Pons, Respiratory timing",
author = "Shaun Morrison and Cravo, {S. L.} and Wilfehrt, {H. M.}",
year = "1994",
month = "7",
day = "25",
doi = "10.1016/0006-8993(94)90320-4",
language = "English (US)",
volume = "652",
pages = "83--86",
journal = "Brain Research",
issn = "0006-8993",
publisher = "Elsevier",
number = "1",

}

TY - JOUR

T1 - Pontine lesions produce apneusis in the rat

AU - Morrison, Shaun

AU - Cravo, S. L.

AU - Wilfehrt, H. M.

PY - 1994/7/25

Y1 - 1994/7/25

N2 - Although lesion experiments in the vagotomized cat have indicated that neurons in the parabrachial region of the dorsolateral pons contribute to the mechanisms involved in terminating inspiration, a similar role for pontine structures in the rat has been questioned since pontomedullary transections in the anesthetized rat failed to prolong inspiration. In the present study, lesions of the parabrachial pons of the decerebrate, unanesthetized rat produced an increase in the duration of inspiration to 400% of control and a doubling of the duration of expiration, suggesting a role for this pontine area in the regulation of the timing of the phases of respiration.

AB - Although lesion experiments in the vagotomized cat have indicated that neurons in the parabrachial region of the dorsolateral pons contribute to the mechanisms involved in terminating inspiration, a similar role for pontine structures in the rat has been questioned since pontomedullary transections in the anesthetized rat failed to prolong inspiration. In the present study, lesions of the parabrachial pons of the decerebrate, unanesthetized rat produced an increase in the duration of inspiration to 400% of control and a doubling of the duration of expiration, suggesting a role for this pontine area in the regulation of the timing of the phases of respiration.

KW - Decerebration

KW - Inspiratory duration

KW - Parabrachial complex

KW - Phrenic nerve

KW - Pons

KW - Respiratory timing

UR - http://www.scopus.com/inward/record.url?scp=0028175498&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028175498&partnerID=8YFLogxK

U2 - 10.1016/0006-8993(94)90320-4

DO - 10.1016/0006-8993(94)90320-4

M3 - Article

C2 - 7953724

AN - SCOPUS:0028175498

VL - 652

SP - 83

EP - 86

JO - Brain Research

JF - Brain Research

SN - 0006-8993

IS - 1

ER -