Polyunsaturated fatty acid regulation of gene expression

Harini Sampath, James M. Ntambi

Research output: Contribution to journalArticle

160 Citations (Scopus)

Abstract

Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.

Original languageEnglish (US)
Pages (from-to)333-339
Number of pages7
JournalNutrition Reviews
Volume62
Issue number9
DOIs
StatePublished - Sep 2004
Externally publishedYes

Fingerprint

gene expression regulation
Gene Expression Regulation
Unsaturated Fatty Acids
polyunsaturated fatty acids
Peroxisome Proliferator-Activated Receptors
Omega-3 Fatty Acids
Membrane Lipids
Cytoplasmic and Nuclear Receptors
Nervous System Diseases
Coronary Disease
nervous system diseases
Adipose Tissue
Signal Transduction
Transcription Factors
lipid composition
Obesity
Stroke
stroke
human diseases
adipose tissue

Keywords

  • HNF-4α
  • LXR α
  • Polyunsaturated fatty acids
  • PPAR-α
  • SREBP1c

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Food Science

Cite this

Polyunsaturated fatty acid regulation of gene expression. / Sampath, Harini; Ntambi, James M.

In: Nutrition Reviews, Vol. 62, No. 9, 09.2004, p. 333-339.

Research output: Contribution to journalArticle

Sampath, Harini ; Ntambi, James M. / Polyunsaturated fatty acid regulation of gene expression. In: Nutrition Reviews. 2004 ; Vol. 62, No. 9. pp. 333-339.
@article{a373cbdfb1c64c68ac1666ce15071770,
title = "Polyunsaturated fatty acid regulation of gene expression",
abstract = "Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.",
keywords = "HNF-4α, LXR α, Polyunsaturated fatty acids, PPAR-α, SREBP1c",
author = "Harini Sampath and Ntambi, {James M.}",
year = "2004",
month = "9",
doi = "10.1301/nr.2004.sept.333-339",
language = "English (US)",
volume = "62",
pages = "333--339",
journal = "Nutrition Reviews",
issn = "0029-6643",
publisher = "Wiley-Blackwell",
number = "9",

}

TY - JOUR

T1 - Polyunsaturated fatty acid regulation of gene expression

AU - Sampath, Harini

AU - Ntambi, James M.

PY - 2004/9

Y1 - 2004/9

N2 - Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.

AB - Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.

KW - HNF-4α

KW - LXR α

KW - Polyunsaturated fatty acids

KW - PPAR-α

KW - SREBP1c

UR - http://www.scopus.com/inward/record.url?scp=4644289020&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=4644289020&partnerID=8YFLogxK

U2 - 10.1301/nr.2004.sept.333-339

DO - 10.1301/nr.2004.sept.333-339

M3 - Article

VL - 62

SP - 333

EP - 339

JO - Nutrition Reviews

JF - Nutrition Reviews

SN - 0029-6643

IS - 9

ER -