Polyunsaturated fatty acid regulation of gene expression

Harini Sampath; James M. Ntambi

doi:10.1301/nr.2004.sept.333-339

Polyunsaturated fatty acid regulation of gene expression

Harini Sampath, James M. Ntambi

Research output: Contribution to journal › Review article › peer-review

197 Scopus citations

Abstract

Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.

Original language	English (US)
Pages (from-to)	333-339
Number of pages	7
Journal	Nutrition Reviews
Volume	62
Issue number	9
DOIs	https://doi.org/10.1301/nr.2004.sept.333-339
State	Published - Sep 2004
Externally published	Yes

Keywords

HNF-4α
LXR α
PPAR-α
Polyunsaturated fatty acids
SREBP1c

ASJC Scopus subject areas

Medicine (miscellaneous)
Nutrition and Dietetics

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10.1301/nr.2004.sept.333-339

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abstract = "Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.",

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AB - Polyunsaturated fatty acids (PUFAs), specifically the n-3 series, have been implicated in the prevention of various human diseases, including obesity, diabetes, coronary heart disease and stroke, and inflammatory and neurologic diseases. PUFAs function mainly by altering membrane lipid composition, cellular metabolism, signal transduction, and regulation of gene expression. PUFAs regulate the expression of genes in various tissues, including the liver, heart, adipose tissue, and brain. The role of transcription factors such as SREBP1c and nuclear receptors such as PPAR-α, HNF-4α, and LXRα in mediating the nuclear effects of PUFAs are addressed.

KW - HNF-4α

KW - LXR α

KW - PPAR-α

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KW - SREBP1c

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Polyunsaturated fatty acid regulation of gene expression

Abstract

Keywords

ASJC Scopus subject areas

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