Polypharmacy in older adults with cancer

Ronald Maggiore, Cary P. Gross, Arti Hurria

Research output: Contribution to journalArticle

98 Citations (Scopus)

Abstract

The definition of "polypharmacy" ranges from the use of a large number of medications; the use of potentially inappropriate medications, which can increase the risk for adverse drug events; medication underuse despite instructions to the contrary; and medication duplication. Older adults are particularly at risk because they often present with several medical conditions requiring pharmacotherapy. Cancerrelated therapy adds to this risk in older adults, but few studies have been conducted in this patient population. In this review, we outline the adverse outcomes associated with polypharmacy and present polypharmacy definitions offered by the geriatrics literature. We also examine the strengths and weaknesses of these definitions and explore the relationships among these definitions and what is known about the prevalence and impact of polypharmacy.

Original languageEnglish (US)
Pages (from-to)507-522
Number of pages16
JournalOncologist
Volume15
Issue number5
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

Polypharmacy
Neoplasms
Drug-Related Side Effects and Adverse Reactions
Geriatrics
Drug Therapy
Population
Therapeutics

Keywords

  • Cancer
  • Geriatrics
  • Medications
  • Oncology
  • Polypharmacy
  • Therapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Maggiore, R., Gross, C. P., & Hurria, A. (2010). Polypharmacy in older adults with cancer. Oncologist, 15(5), 507-522. https://doi.org/10.1634/theoncologist.2009-0290

Polypharmacy in older adults with cancer. / Maggiore, Ronald; Gross, Cary P.; Hurria, Arti.

In: Oncologist, Vol. 15, No. 5, 2010, p. 507-522.

Research output: Contribution to journalArticle

Maggiore, R, Gross, CP & Hurria, A 2010, 'Polypharmacy in older adults with cancer', Oncologist, vol. 15, no. 5, pp. 507-522. https://doi.org/10.1634/theoncologist.2009-0290
Maggiore, Ronald ; Gross, Cary P. ; Hurria, Arti. / Polypharmacy in older adults with cancer. In: Oncologist. 2010 ; Vol. 15, No. 5. pp. 507-522.
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