Polyoma virus nephropathy-related mass lesion in an apparently immunocompetent patient

Stephanie Go, Michael Conlin, Jody Hooper, Megan Troxell

    Research output: Contribution to journalArticlepeer-review

    1 Scopus citations

    Abstract

    Polyoma virus is a recognized cause of hemorrhagic cystitis, viral nephropathy, and ureteral stricture in renal and stem cell transplant recipients. Rarely, polyoma virus causes native kidney and bladder pathology in heavily immunosuppressed patients. We report a unique case of native kidney polyoma virus nephropathy, urothelial ulceration, and renal pelvic fibrosis presenting as a mass lesion in a non-debilitated, apparently immunocompetent man. Based on radiologic, ureterorenoscopic, and urine cytologic findings, a laparoscopic nephrectomy was performed. However, nephrectomy revealed a hemorrhagic scar-like lesion, with urothelial ulceration, but no neoplasm or malignancy. Histopathologic evaluation and immunostaining revealed polyoma viral infection in the nearby renal medulla. This case adds polyoma virus nephropathy to the differential diagnosis of non-neoplastic and reactive masses, which may mimic renal malignancy.

    Original languageEnglish (US)
    Pages (from-to)1585-1588
    Number of pages4
    JournalInternational Urology and Nephrology
    Volume44
    Issue number5
    DOIs
    StatePublished - Oct 1 2012

    Keywords

    • BK nephropathy
    • Immunocompromised
    • Polyoma virus
    • Renal mass

    ASJC Scopus subject areas

    • Nephrology
    • Urology

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