Polyoma virus nephropathy-related mass lesion in an apparently immunocompetent patient

Stephanie Go, Michael Conlin, Jody E. Hooper, Megan Troxell

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Polyoma virus is a recognized cause of hemorrhagic cystitis, viral nephropathy, and ureteral stricture in renal and stem cell transplant recipients. Rarely, polyoma virus causes native kidney and bladder pathology in heavily immunosuppressed patients. We report a unique case of native kidney polyoma virus nephropathy, urothelial ulceration, and renal pelvic fibrosis presenting as a mass lesion in a non-debilitated, apparently immunocompetent man. Based on radiologic, ureterorenoscopic, and urine cytologic findings, a laparoscopic nephrectomy was performed. However, nephrectomy revealed a hemorrhagic scar-like lesion, with urothelial ulceration, but no neoplasm or malignancy. Histopathologic evaluation and immunostaining revealed polyoma viral infection in the nearby renal medulla. This case adds polyoma virus nephropathy to the differential diagnosis of non-neoplastic and reactive masses, which may mimic renal malignancy.

Original languageEnglish (US)
Pages (from-to)1585-1588
Number of pages4
JournalInternational Urology and Nephrology
Volume44
Issue number5
DOIs
StatePublished - Oct 2012

Fingerprint

Polyomavirus
Kidney
Nephrectomy
Neoplasms
Cystitis
Virus Diseases
Cicatrix
Pathologic Constriction
Urinary Bladder
Differential Diagnosis
Fibrosis
Stem Cells
Urine
Pathology
Transplants

Keywords

  • BK nephropathy
  • Immunocompromised
  • Polyoma virus
  • Renal mass

ASJC Scopus subject areas

  • Nephrology
  • Urology

Cite this

Polyoma virus nephropathy-related mass lesion in an apparently immunocompetent patient. / Go, Stephanie; Conlin, Michael; Hooper, Jody E.; Troxell, Megan.

In: International Urology and Nephrology, Vol. 44, No. 5, 10.2012, p. 1585-1588.

Research output: Contribution to journalArticle

Go, Stephanie ; Conlin, Michael ; Hooper, Jody E. ; Troxell, Megan. / Polyoma virus nephropathy-related mass lesion in an apparently immunocompetent patient. In: International Urology and Nephrology. 2012 ; Vol. 44, No. 5. pp. 1585-1588.
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