Polymorphisms of GSTT1 and related genes in head and neck cancer risk

Adam J. Evans; William David Henner; Kristi M. Eilers; Michelle A. Montalto; Emily M. Wersinger; Peter E. Andersen; James I. Cohen; Edwin C. Everts; Jeffrey E. McWilliams; Tomasz M. Beer

doi:10.1002/hed.10342

Polymorphisms of GSTT1 and related genes in head and neck cancer risk

Adam J. Evans, William David Henner, Kristi M. Eilers, Michelle A. Montalto, Emily M. Wersinger, Peter E. Andersen, James I. Cohen, Edwin C. Everts, Jeffrey E. McWilliams, Tomasz M. Beer

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

Background. Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). Methods. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population-based controls. Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1-2.5, p = .03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5-6.3) and men (OR, 1.2; CI, 0.7-2.1) for the presence of GSTT1. Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women.

Original language	English (US)
Pages (from-to)	63-70
Number of pages	8
Journal	Head and Neck
Volume	26
Issue number	1
DOIs	https://doi.org/10.1002/hed.10342
State	Published - Jan 2004

Keywords

CYP1A1
Epidemiology
GSTM1
GSTP1
GSTT1
Glutathione transferases
Head and neck cancer

ASJC Scopus subject areas

Otorhinolaryngology

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10.1002/hed.10342

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title = "Polymorphisms of GSTT1 and related genes in head and neck cancer risk",

abstract = "Background. Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). Methods. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population-based controls. Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1-2.5, p = .03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5-6.3) and men (OR, 1.2; CI, 0.7-2.1) for the presence of GSTT1. Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women.",

keywords = "CYP1A1, Epidemiology, GSTM1, GSTP1, GSTT1, Glutathione transferases, Head and neck cancer",

author = "Evans, {Adam J.} and Henner, {William David} and Eilers, {Kristi M.} and Montalto, {Michelle A.} and Wersinger, {Emily M.} and Andersen, {Peter E.} and Cohen, {James I.} and Everts, {Edwin C.} and McWilliams, {Jeffrey E.} and Beer, {Tomasz M.}",

year = "2004",

month = jan,

doi = "10.1002/hed.10342",

language = "English (US)",

volume = "26",

pages = "63--70",

journal = "Head and Neck",

issn = "1043-3074",

publisher = "Wiley-Liss Inc.",

number = "1",

}

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T1 - Polymorphisms of GSTT1 and related genes in head and neck cancer risk

AU - Evans, Adam J.

AU - Henner, William David

AU - Eilers, Kristi M.

AU - Montalto, Michelle A.

AU - Wersinger, Emily M.

AU - Andersen, Peter E.

AU - Cohen, James I.

AU - Everts, Edwin C.

AU - McWilliams, Jeffrey E.

AU - Beer, Tomasz M.

PY - 2004/1

Y1 - 2004/1

N2 - Background. Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). Methods. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population-based controls. Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1-2.5, p = .03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5-6.3) and men (OR, 1.2; CI, 0.7-2.1) for the presence of GSTT1. Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women.

AB - Background. Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). Methods. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population-based controls. Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1-2.5, p = .03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5-6.3) and men (OR, 1.2; CI, 0.7-2.1) for the presence of GSTT1. Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women.

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KW - Epidemiology

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KW - Glutathione transferases

KW - Head and neck cancer

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Polymorphisms of GSTT1 and related genes in head and neck cancer risk

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