Polymorphisms of GSTT1 and related genes in head and neck cancer risk

Adam J. Evans, William David Henner, Kristi M. Eilers, Michelle A. Montalto, Emily M. Wersinger, Peter E. Andersen, James I. Cohen, Edwin C. Everts, Jeffrey E. McWilliams, Tomasz M. Beer

Research output: Contribution to journalArticle

34 Scopus citations

Abstract

Background. Glutathione S-transferase T1 detoxifies some environmental carcinogens while activating others and is deleted in 15% to 38% of humans. We sought to determine whether GSTT1 genotype and genotypes of several related genes are associated with risk of squamous cell carcinoma of the head and neck (HNSCC). Methods. Somatic genotypes for GSTT1, GSTM1, GSTP1, and CYP1A1 were determined in 283 individuals with HNSCC and 208 population-based controls. Results. The OR for presence of GSTT1 was 1.6 (CI, 1.1-2.5, p = .03). HNSCC risk was not associated with GSTM1 null genotype, the presence of the GSTP1 Val/Val genotype, or the Val/Val homozygous genotype for CYP1A1. Stratified analysis revealed disparate ORs for women (OR, 3.0; CI, 1.5-6.3) and men (OR, 1.2; CI, 0.7-2.1) for the presence of GSTT1. Conclusions. In this population, the presence of GSTT1 gene was associated with a significant increase in the risk of HNSCC. This association was particularly robust in women.

Original languageEnglish (US)
Pages (from-to)63-70
Number of pages8
JournalHead and Neck
Volume26
Issue number1
DOIs
StatePublished - Jan 1 2004

Keywords

  • CYP1A1
  • Epidemiology
  • GSTM1
  • GSTP1
  • GSTT1
  • Glutathione transferases
  • Head and neck cancer

ASJC Scopus subject areas

  • Otorhinolaryngology

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    Evans, A. J., Henner, W. D., Eilers, K. M., Montalto, M. A., Wersinger, E. M., Andersen, P. E., Cohen, J. I., Everts, E. C., McWilliams, J. E., & Beer, T. M. (2004). Polymorphisms of GSTT1 and related genes in head and neck cancer risk. Head and Neck, 26(1), 63-70. https://doi.org/10.1002/hed.10342