Polymorphisms in TICAM2 and IL1B are associated with TB

Tuberculosis Research Unit (TBRU)

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24 Scopus citations

Abstract

Human genetic susceptibility for tuberculosis (TB) has been demonstrated by several studies, but few have examined the multiple innate and adaptive immunity genes comprehensively, age-specific effects and/or resistance to Mycobacterium tuberculosis (Mtb) infection (resistors (RSTRs)). We hypothesized that RSTRs, defined by a persistently negative tuberculin skin test, may have different genetic influences than Mtb disease. We examined 29 candidate genes in pathways that mediate immune responses to Mtb in subjects in a household contact study in Kampala, Uganda. We genotyped 546 haplotype-tagging single-nucleotide polymorphisms (SNPs) in 835 individuals from 481 families; 28.7% had TB, 10.5% were RSTRs, and the remaining 60.8% had latent Mtb infection. Among our most significant findings were SNPs in TICAM2 (P=3.6 × 10-6) and IL1B (P=4.3 × 10-5) associated with TB. Multiple SNPs in IL4 and TOLLIP were associated with TB (P-3). By contrast, RSTR was associated with SNPs in NOD2, SLC6A3 and TLR4 (nominal P

Original languageEnglish (US)
Pages (from-to)127-133
Number of pages7
JournalGenes and Immunity
Volume16
Issue number2
DOIs
Publication statusPublished - Mar 1 2015

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ASJC Scopus subject areas

  • Genetics(clinical)
  • Immunology
  • Genetics

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