Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians

Gurvinder Kaur, P. Singh, C. C. Rapthap, N. Kumar, M. Vajpayee, S. K. Sharma, A. Wanchu, N. K. Mehra

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33 Scopus citations

Abstract

The clinical course and outcome of human immunodeficiency virus-1 (HIV-1) infection are highly variable among individuals. CCR5 is the primary coreceptor that mediates entry of HIV-1 (R5) into permissive host cells. In this study, five SNPs (59029G/A, 59353T/C, 59356C/T, 59402A/G, and 59653C/T) in the promoter region and a deletion of 32 bp (Δ32) in the CCR5 gene were evaluated in 180 chronically HIV-1-infected North Indians. The study showed the following: (1) the protective CCR5 Δ32 allele was absent; (2) the frequency of CCR5*59402A allele in the HIV-infected people (66.4%) was higher than in healthy subjects (57.1%, p = 0.027) and in the CDC stage C patients (76%) versus stages A and B patients together (60%; p = 0.002); (3) homozygous CCR5*59402 AA genotype was significantly increased in the seropositive subjects (46.1%) compared with healthy control subjects (30.2%; p = 0.008) and in the CDC stage C patients (59.2%) compared with stage A and B subjects (37.6%, p = 0.007); and (4) an increased frequency of homozygous ACCAC haplotype was present in the seropositive stage C patients (32.4%) versus 15.6% in patients in stages A plus B (p = 0.013). These observations suggest an association of CCR5*59402A with increased likelihood of acquisition of HIV-1 and development of AIDS in the Asian Indian population. Further studies are required to confirm these findings and understand the effect of CCR5 polymorphisms on the outcome of HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalHuman Immunology
Volume68
Issue number5
DOIs
StatePublished - May 1 2007

Keywords

  • AIDS
  • CCR5
  • Chemokine receptors
  • HIV-1
  • polymorphism

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology

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    Kaur, G., Singh, P., Rapthap, C. C., Kumar, N., Vajpayee, M., Sharma, S. K., Wanchu, A., & Mehra, N. K. (2007). Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians. Human Immunology, 68(5), 454-461. https://doi.org/10.1016/j.humimm.2007.01.016