Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians

Gurvinder Kaur, P. Singh, C. C. Rapthap, N. Kumar, M. Vajpayee, S. K. Sharma, Ajay Wanchu, N. K. Mehra

Research output: Contribution to journalArticle

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Abstract

The clinical course and outcome of human immunodeficiency virus-1 (HIV-1) infection are highly variable among individuals. CCR5 is the primary coreceptor that mediates entry of HIV-1 (R5) into permissive host cells. In this study, five SNPs (59029G/A, 59353T/C, 59356C/T, 59402A/G, and 59653C/T) in the promoter region and a deletion of 32 bp (Δ32) in the CCR5 gene were evaluated in 180 chronically HIV-1-infected North Indians. The study showed the following: (1) the protective CCR5 Δ32 allele was absent; (2) the frequency of CCR5*59402A allele in the HIV-infected people (66.4%) was higher than in healthy subjects (57.1%, p = 0.027) and in the CDC stage C patients (76%) versus stages A and B patients together (60%; p = 0.002); (3) homozygous CCR5*59402 AA genotype was significantly increased in the seropositive subjects (46.1%) compared with healthy control subjects (30.2%; p = 0.008) and in the CDC stage C patients (59.2%) compared with stage A and B subjects (37.6%, p = 0.007); and (4) an increased frequency of homozygous ACCAC haplotype was present in the seropositive stage C patients (32.4%) versus 15.6% in patients in stages A plus B (p = 0.013). These observations suggest an association of CCR5*59402A with increased likelihood of acquisition of HIV-1 and development of AIDS in the Asian Indian population. Further studies are required to confirm these findings and understand the effect of CCR5 polymorphisms on the outcome of HIV-1 infection.

Original languageEnglish (US)
Pages (from-to)454-461
Number of pages8
JournalHuman Immunology
Volume68
Issue number5
DOIs
StatePublished - May 2007
Externally publishedYes

Fingerprint

Virus Diseases
HIV-1
Genes
Centers for Disease Control and Prevention (U.S.)
Healthy Volunteers
Alleles
Genetic Promoter Regions
Haplotypes
Single Nucleotide Polymorphism
Acquired Immunodeficiency Syndrome
Genotype
HIV
Population

Keywords

  • AIDS
  • CCR5
  • Chemokine receptors
  • HIV-1
  • polymorphism

ASJC Scopus subject areas

  • Immunology
  • Immunology and Allergy

Cite this

Kaur, G., Singh, P., Rapthap, C. C., Kumar, N., Vajpayee, M., Sharma, S. K., ... Mehra, N. K. (2007). Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians. Human Immunology, 68(5), 454-461. https://doi.org/10.1016/j.humimm.2007.01.016

Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians. / Kaur, Gurvinder; Singh, P.; Rapthap, C. C.; Kumar, N.; Vajpayee, M.; Sharma, S. K.; Wanchu, Ajay; Mehra, N. K.

In: Human Immunology, Vol. 68, No. 5, 05.2007, p. 454-461.

Research output: Contribution to journalArticle

Kaur, G, Singh, P, Rapthap, CC, Kumar, N, Vajpayee, M, Sharma, SK, Wanchu, A & Mehra, NK 2007, 'Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians', Human Immunology, vol. 68, no. 5, pp. 454-461. https://doi.org/10.1016/j.humimm.2007.01.016
Kaur G, Singh P, Rapthap CC, Kumar N, Vajpayee M, Sharma SK et al. Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians. Human Immunology. 2007 May;68(5):454-461. https://doi.org/10.1016/j.humimm.2007.01.016
Kaur, Gurvinder ; Singh, P. ; Rapthap, C. C. ; Kumar, N. ; Vajpayee, M. ; Sharma, S. K. ; Wanchu, Ajay ; Mehra, N. K. / Polymorphism in the CCR5 Gene Promoter and HIV-1 Infection in North Indians. In: Human Immunology. 2007 ; Vol. 68, No. 5. pp. 454-461.
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