Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Pengyu Gu, Jiaxin Gong, Ye Shang, Fei Wang, Kendra T. Ruppell, Zhiguo Ma, Amy E. Sheehan, Marc R. Freeman, Yang Xiang

Research output: Contribution to journalArticle

Abstract

Gu et al. demonstrate that heat and UVC light preferentially activate distinct Drosophila TrpA1 isoforms in vivo, and polymodal nociception requires co-expression of TrpA1-C and TrpA1-D.

Original languageEnglish (US)
Pages (from-to)3961-3973.e6
JournalCurrent Biology
Volume29
Issue number23
DOIs
StatePublished - Dec 2 2019

Keywords

  • Drosophila
  • TrpA1
  • alternative splicing
  • genome engineering
  • nociception
  • polymodal nociceptors
  • thermogenetics
  • transient receptor potential
  • translational reporters

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

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  • Cite this

    Gu, P., Gong, J., Shang, Y., Wang, F., Ruppell, K. T., Ma, Z., Sheehan, A. E., Freeman, M. R., & Xiang, Y. (2019). Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1. Current Biology, 29(23), 3961-3973.e6. https://doi.org/10.1016/j.cub.2019.09.070