@article{45fa424de54d4d7ea38e9929e398801c,
title = "Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1",
abstract = "Gu et al. demonstrate that heat and UVC light preferentially activate distinct Drosophila TrpA1 isoforms in vivo, and polymodal nociception requires co-expression of TrpA1-C and TrpA1-D.",
keywords = "Drosophila, TrpA1, alternative splicing, genome engineering, nociception, polymodal nociceptors, thermogenetics, transient receptor potential, translational reporters",
author = "Pengyu Gu and Jiaxin Gong and Ye Shang and Fei Wang and Ruppell, {Kendra T.} and Zhiguo Ma and Sheehan, {Amy E.} and Freeman, {Marc R.} and Yang Xiang",
note = "Funding Information: We thank Drs. Yang Hong and Juan Huang for reagents and advice for genomic engineering; Drs. Michael Galko and Seol Hee Im for instructions on heat nociceptive behavioral assay; Drs. Paul Garrity, Bing Ye, Patrick Emery, and Chun Han for sharing reagents; the Bloomington Stock Center for providing fly stocks; and Drs. Patrick Emery, David Weaver, Bing Ye, Fan Wang, Rebecca Yang, Yang Hong, and Weisheng Chen for critical comments on the manuscript. We thank Peng Ding and Michael G. Gorczyca for technical support. Y.X. is supported by the National Institutes of Health under award numbers 5R01NS089787 and 1R21NS107924 and Human Frontier Science Program Young Investigator award RGY0090/2014 . M.F. is supported by the National Institutes of Health under award number 5R37NS053538 . Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",
year = "2019",
month = dec,
day = "2",
doi = "10.1016/j.cub.2019.09.070",
language = "English (US)",
volume = "29",
pages = "3961--3973.e6",
journal = "Current Biology",
issn = "0960-9822",
publisher = "Cell Press",
number = "23",
}