Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Pengyu Gu; Jiaxin Gong; Ye Shang; Fei Wang; Kendra T. Ruppell; Zhiguo Ma; Amy E. Sheehan; Marc R. Freeman; Yang Xiang

doi:10.1016/j.cub.2019.09.070

Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Pengyu Gu, Jiaxin Gong, Ye Shang, Fei Wang, Kendra T. Ruppell, Zhiguo Ma, Amy E. Sheehan, Marc R. Freeman, Yang Xiang

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

Gu et al. demonstrate that heat and UVC light preferentially activate distinct Drosophila TrpA1 isoforms in vivo, and polymodal nociception requires co-expression of TrpA1-C and TrpA1-D.

Original language	English (US)
Pages (from-to)	3961-3973.e6
Journal	Current Biology
Volume	29
Issue number	23
DOIs	https://doi.org/10.1016/j.cub.2019.09.070
State	Published - Dec 2 2019
Externally published	Yes

Keywords

Drosophila
TrpA1
alternative splicing
genome engineering
nociception
polymodal nociceptors
thermogenetics
transient receptor potential
translational reporters

ASJC Scopus subject areas

General Neuroscience
General Biochemistry, Genetics and Molecular Biology
General Agricultural and Biological Sciences

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10.1016/j.cub.2019.09.070

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title = "Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1",

abstract = "Gu et al. demonstrate that heat and UVC light preferentially activate distinct Drosophila TrpA1 isoforms in vivo, and polymodal nociception requires co-expression of TrpA1-C and TrpA1-D.",

keywords = "Drosophila, TrpA1, alternative splicing, genome engineering, nociception, polymodal nociceptors, thermogenetics, transient receptor potential, translational reporters",

author = "Pengyu Gu and Jiaxin Gong and Ye Shang and Fei Wang and Ruppell, {Kendra T.} and Zhiguo Ma and Sheehan, {Amy E.} and Freeman, {Marc R.} and Yang Xiang",

note = "Publisher Copyright: {\textcopyright} 2019 Elsevier Ltd",

year = "2019",

month = dec,

day = "2",

doi = "10.1016/j.cub.2019.09.070",

language = "English (US)",

volume = "29",

pages = "3961--3973.e6",

journal = "Current Biology",

issn = "0960-9822",

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T1 - Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

AU - Gu, Pengyu

AU - Gong, Jiaxin

AU - Shang, Ye

AU - Wang, Fei

AU - Ruppell, Kendra T.

AU - Ma, Zhiguo

AU - Sheehan, Amy E.

AU - Freeman, Marc R.

AU - Xiang, Yang

PY - 2019/12/2

Y1 - 2019/12/2

N2 - Gu et al. demonstrate that heat and UVC light preferentially activate distinct Drosophila TrpA1 isoforms in vivo, and polymodal nociception requires co-expression of TrpA1-C and TrpA1-D.

AB - Gu et al. demonstrate that heat and UVC light preferentially activate distinct Drosophila TrpA1 isoforms in vivo, and polymodal nociception requires co-expression of TrpA1-C and TrpA1-D.

KW - Drosophila

KW - TrpA1

KW - alternative splicing

KW - genome engineering

KW - nociception

KW - polymodal nociceptors

KW - thermogenetics

KW - transient receptor potential

KW - translational reporters

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M3 - Article

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AN - SCOPUS:85075459602

SN - 0960-9822

VL - 29

SP - 3961-3973.e6

JO - Current Biology

JF - Current Biology

IS - 23

ER -

Polymodal Nociception in Drosophila Requires Alternative Splicing of TrpA1

Abstract

Keywords

ASJC Scopus subject areas

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