Polymerizing actin fibers position integrins primed to probe for adhesion sites

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201 Scopus citations

Abstract

Migrating cells extend protrusions, probing the surrounding matrix in search of permissive sites to form adhesions. We found that actin fibers polymerizing along the leading edge directed local protrusions and drove synchronous sideways movement of β1 integrin adhesion receptors. These movements lead to the clustering and positioning of conformationally activated, but unligated, β1 integrins along the leading edge of fibroblast lamellae and growth cone filopodia. Thus, rapid actin-based movement of primed integrins along the leading edge suggests a "sticky fingers" mechanism to probe for new adhesion sites and to direct migration.

Original languageEnglish (US)
Pages (from-to)992-995
Number of pages4
JournalScience
Volume315
Issue number5814
DOIs
StatePublished - Feb 16 2007

ASJC Scopus subject areas

  • General

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