Polymer Modeling Predicts Chromosome Reorganization in Senescence

Michael Chiang, Davide Michieletto, Chris A. Brackley, Nattaphong Rattanavirotkul, Hisham Mohammed, Davide Marenduzzo, Tamir Chandra

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Chiang et al. use polymer simulations to investigate the roles of heterochromatin and lamina interactions on nuclear reorganization in cellular senescence. Their model captures chromatin organization in growing, senescent, and progeroid cells and predicts that a polymeric phase transition underlies the ensuing rearrangements in the chromatin contact network.

Original languageEnglish (US)
Pages (from-to)3212-3223.e6
JournalCell Reports
Volume28
Issue number12
DOIs
StatePublished - Sep 17 2019

Keywords

  • cellular senescence
  • genome organization
  • heterochromatin
  • nuclear lamina
  • phase transitions
  • polymer simulations
  • progeria

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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