@article{061ae9931f7d48db98112b65249f27e4,
title = "Polymer Modeling Predicts Chromosome Reorganization in Senescence",
abstract = "Chiang et al. use polymer simulations to investigate the roles of heterochromatin and lamina interactions on nuclear reorganization in cellular senescence. Their model captures chromatin organization in growing, senescent, and progeroid cells and predicts that a polymeric phase transition underlies the ensuing rearrangements in the chromatin contact network.",
keywords = "cellular senescence, genome organization, heterochromatin, nuclear lamina, phase transitions, polymer simulations, progeria",
author = "Michael Chiang and Davide Michieletto and Brackley, {Chris A.} and Nattaphong Rattanavirotkul and Hisham Mohammed and Davide Marenduzzo and Tamir Chandra",
note = "Funding Information: D. Michieletto, C.A.B., and D. Marenduzzo acknowledge the European Research Council for funding (Consolidator Grant THREEDCELLPHYSICS, Ref. 648050 ). M.C. acknowledges the Carnegie Trust for the Universities of Scotland for PhD studentship funding. T.C. is supported by a Chancellor{\textquoteright}s Fellowship held at the University of Edinburgh and the MRC Human Genetics Unit. N.R. was supported by a PhD studentship funded by the Wellcome Trust Sanger Institute and the Royal Thai Government . We would like to acknowledge the Cambridge Centre for Proteomics for the mass spectrometry analysis. We would also like to thank N. Robertson for preparing the bioinformatics data required for the simulations. Funding Information: D. Michieletto, C.A.B. and D. Marenduzzo acknowledge the European Research Council for funding (Consolidator Grant THREEDCELLPHYSICS, Ref. 648050). M.C. acknowledges the Carnegie Trust for the Universities of Scotland for PhD studentship funding. T.C. is supported by a Chancellor's Fellowship held at the University of Edinburgh and the MRC Human Genetics Unit. N.R. was supported by a PhD studentship funded by the Wellcome Trust Sanger Institute and the Royal Thai Government. We would like to acknowledge the Cambridge Centre for Proteomics for the mass spectrometry analysis. We would also like to thank N. Robertson for preparing the bioinformatics data required for the simulations. M.C. D. Michieletto, C.A.B. D. Marenduzzo, and T.C. designed the research and discussed the results. M.C. performed the simulations. M.C. and C.A.B. analyzed the Hi-C data. N.R. H.M. and T.C. performed the imaging, chromatin fractionation, and mass spectrometry experiments. All of the authors wrote the paper. The authors declare no competing interests. Publisher Copyright: {\textcopyright} 2019 The Authors",
year = "2019",
month = sep,
day = "17",
doi = "10.1016/j.celrep.2019.08.045",
language = "English (US)",
volume = "28",
pages = "3212--3223.e6",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "12",
}