Polymer Modeling Predicts Chromosome Reorganization in Senescence

Michael Chiang; Davide Michieletto; Chris A. Brackley; Nattaphong Rattanavirotkul; Hisham Mohammed; Davide Marenduzzo; Tamir Chandra

doi:10.1016/j.celrep.2019.08.045

Polymer Modeling Predicts Chromosome Reorganization in Senescence

Michael Chiang, Davide Michieletto, Chris A. Brackley, Nattaphong Rattanavirotkul, Hisham Mohammed, Davide Marenduzzo, Tamir Chandra

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46 Scopus citations

Abstract

Chiang et al. use polymer simulations to investigate the roles of heterochromatin and lamina interactions on nuclear reorganization in cellular senescence. Their model captures chromatin organization in growing, senescent, and progeroid cells and predicts that a polymeric phase transition underlies the ensuing rearrangements in the chromatin contact network.

Original language	English (US)
Pages (from-to)	3212-3223.e6
Journal	Cell Reports
Volume	28
Issue number	12
DOIs	https://doi.org/10.1016/j.celrep.2019.08.045
State	Published - Sep 17 2019

Keywords

cellular senescence
genome organization
heterochromatin
nuclear lamina
phase transitions
polymer simulations
progeria

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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10.1016/j.celrep.2019.08.045

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title = "Polymer Modeling Predicts Chromosome Reorganization in Senescence",

abstract = "Chiang et al. use polymer simulations to investigate the roles of heterochromatin and lamina interactions on nuclear reorganization in cellular senescence. Their model captures chromatin organization in growing, senescent, and progeroid cells and predicts that a polymeric phase transition underlies the ensuing rearrangements in the chromatin contact network.",

keywords = "cellular senescence, genome organization, heterochromatin, nuclear lamina, phase transitions, polymer simulations, progeria",

author = "Michael Chiang and Davide Michieletto and Brackley, {Chris A.} and Nattaphong Rattanavirotkul and Hisham Mohammed and Davide Marenduzzo and Tamir Chandra",

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AU - Chiang, Michael

AU - Michieletto, Davide

AU - Brackley, Chris A.

AU - Rattanavirotkul, Nattaphong

AU - Mohammed, Hisham

AU - Marenduzzo, Davide

AU - Chandra, Tamir

PY - 2019/9/17

Y1 - 2019/9/17

N2 - Chiang et al. use polymer simulations to investigate the roles of heterochromatin and lamina interactions on nuclear reorganization in cellular senescence. Their model captures chromatin organization in growing, senescent, and progeroid cells and predicts that a polymeric phase transition underlies the ensuing rearrangements in the chromatin contact network.

AB - Chiang et al. use polymer simulations to investigate the roles of heterochromatin and lamina interactions on nuclear reorganization in cellular senescence. Their model captures chromatin organization in growing, senescent, and progeroid cells and predicts that a polymeric phase transition underlies the ensuing rearrangements in the chromatin contact network.

KW - cellular senescence

KW - genome organization

KW - heterochromatin

KW - nuclear lamina

KW - phase transitions

KW - polymer simulations

KW - progeria

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SN - 2211-1247

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SP - 3212-3223.e6

JO - Cell Reports

JF - Cell Reports

IS - 12

ER -

Polymer Modeling Predicts Chromosome Reorganization in Senescence

Abstract

Keywords

ASJC Scopus subject areas

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