Polydimethylsiloxane/polyether-mixed macrodiol-based polyurethane elastomers: Biostability

Darren J. Martin, Laura A. Poole Warren, Pathiraja A. Gunatillake, Simon J. McCarthy, Gordon F. Meijs, Klaus Schindhelm

Research output: Contribution to journalArticle

150 Scopus citations

Abstract

A series of four thermoplastic polyurethane elastomers were synthesized with varying proportions of poly(hexamethylene oxide) (PHMO) and poly(dimethylsiloxane) (PDMS) macrodiols. The macrodiol ratios (by weight) employed were (% PDMS:%PHMO) 100:0, 80:20, 50:50 and 20:80. The weight fraction of macrodiol in each polymer was fixed at 60%. The mixed macrodiols were reacted with 4,4'-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BDO) chain extender. The biostability of these polymers was assessed by strained subcutaneous implantation in sheep for three months followed by microscopic examination. Pellethane 2363-80A and 2363-55D were employed as control materials. The mechanical properties of the polymers were tested and discussed along with the biostability results. The results showed that soft, flexible PDMS-based polyurethanes with very promising biostability can be successfully produced using the mixed macrodiol approach. The formulation with 80% PDMS macrodiol produced the best result in terms of a combination of flexibility, strength and biostability. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)1021-1029
Number of pages9
JournalBiomaterials
Volume21
Issue number10
DOIs
StatePublished - May 1 2000

    Fingerprint

Keywords

  • Biostability
  • Degradation
  • Environmental stress cracking (ESC)
  • Poly(dimethylsiloxane)
  • Polyurethanes

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Martin, D. J., Poole Warren, L. A., Gunatillake, P. A., McCarthy, S. J., Meijs, G. F., & Schindhelm, K. (2000). Polydimethylsiloxane/polyether-mixed macrodiol-based polyurethane elastomers: Biostability. Biomaterials, 21(10), 1021-1029. https://doi.org/10.1016/S0142-9612(99)00271-9