Polydimethylsiloxane/polyether-mixed macrodiol-based polyurethane elastomers: Biostability

Darren J. Martin, Laura A. Poole Warren, Pathiraja A. Gunatillake, Simon J. McCarthy, Gordon F. Meijs, Klaus Schindhelm

Research output: Contribution to journalArticlepeer-review

167 Scopus citations


A series of four thermoplastic polyurethane elastomers were synthesized with varying proportions of poly(hexamethylene oxide) (PHMO) and poly(dimethylsiloxane) (PDMS) macrodiols. The macrodiol ratios (by weight) employed were (% PDMS:%PHMO) 100:0, 80:20, 50:50 and 20:80. The weight fraction of macrodiol in each polymer was fixed at 60%. The mixed macrodiols were reacted with 4,4'-methylenediphenyl diisocyanate (MDI) and 1,4-butanediol (BDO) chain extender. The biostability of these polymers was assessed by strained subcutaneous implantation in sheep for three months followed by microscopic examination. Pellethane 2363-80A and 2363-55D were employed as control materials. The mechanical properties of the polymers were tested and discussed along with the biostability results. The results showed that soft, flexible PDMS-based polyurethanes with very promising biostability can be successfully produced using the mixed macrodiol approach. The formulation with 80% PDMS macrodiol produced the best result in terms of a combination of flexibility, strength and biostability. Copyright (C) 2000 Elsevier Science B.V.

Original languageEnglish (US)
Pages (from-to)1021-1029
Number of pages9
Issue number10
StatePublished - May 2000


  • Biostability
  • Degradation
  • Environmental stress cracking (ESC)
  • Poly(dimethylsiloxane)
  • Polyurethanes

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials


Dive into the research topics of 'Polydimethylsiloxane/polyether-mixed macrodiol-based polyurethane elastomers: Biostability'. Together they form a unique fingerprint.

Cite this