Polyamine biosynthetic enzymes as drug targets in parasitic protozoa

O. Heby, S. C. Roberts, Buddy Ullman

Research output: Contribution to journalArticle

70 Citations (Scopus)

Abstract

Molecular, biochemical and genetic characterization of ornithine decarboxylase, S-adenosylmethionine decarboxylase and spermidine synthase establishes that these polyamine-biosynthetic enzymes are essential for growth and survival of the agents that cause African sleeping sickness, Chagas' disease, leishmaniasis and malaria. These enzymes exhibit features that differ significantly between the parasites and the human host. Therefore it is conceivable that exploitation of such differences can lead to the design of new inhibitors that will selectively kill the parasites while exerting minimal, or at least tolerable, effects on the parasite-infected patient.

Original languageEnglish (US)
Pages (from-to)415-419
Number of pages5
JournalBiochemical Society Transactions
Volume31
Issue number2
DOIs
StatePublished - Apr 2003

Fingerprint

Protozoa
Polyamines
Parasites
Molecular Biology
Spermidine Synthase
Enzymes
Adenosylmethionine Decarboxylase
Pharmaceutical Preparations
African Trypanosomiasis
Ornithine Decarboxylase
Leishmaniasis
Chagas Disease
Malaria
Survival
Growth

Keywords

  • African sleeping sickness
  • Chagas' disease
  • Leishmaniasis
  • Malaria
  • Polyamine

ASJC Scopus subject areas

  • Biochemistry

Cite this

Polyamine biosynthetic enzymes as drug targets in parasitic protozoa. / Heby, O.; Roberts, S. C.; Ullman, Buddy.

In: Biochemical Society Transactions, Vol. 31, No. 2, 04.2003, p. 415-419.

Research output: Contribution to journalArticle

Heby, O. ; Roberts, S. C. ; Ullman, Buddy. / Polyamine biosynthetic enzymes as drug targets in parasitic protozoa. In: Biochemical Society Transactions. 2003 ; Vol. 31, No. 2. pp. 415-419.
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