Poison Ivy/Oak Dermatitis

Use of Polyamine Salts of a Linoleic Acid Dimer for Topical Prophylaxis

Susan Orchard, Jack H. Fellman, Frances Storrs

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Closed patch tests were used to evaluate the ability of 156 different preparations (based on 22 different chemicals) to prevent poison ivy dermatitis. Several polyamine salts of a linoleic acid dimer were identified that were totally able to prevent the usual dermatitis in approximately 70% of subjects. The effectiveness of the preparations improved when the antigen and the protectant were washed off within eight to 12 hours, instead of remaining on the skin for 48 hours. When washed off, and depending on the protectant, concentration, and vehicle used, several of the preparations were totally able to prevent a dermatitis in a range of 56% to 100% of subjects tested. Further work with these compounds may greatly benefit the many people currently plagued by their allergy to poison ivy and poison oak.

Original languageEnglish (US)
Pages (from-to)783-789
Number of pages7
JournalArchives of Dermatology
Volume122
Issue number7
DOIs
StatePublished - 1986

Fingerprint

Toxicodendron Dermatitis
Toxicodendron
Polyamines
Dermatitis
Linoleic Acid
Salts
Patch Tests
Hypersensitivity
Antigens
Skin

ASJC Scopus subject areas

  • Dermatology

Cite this

Poison Ivy/Oak Dermatitis : Use of Polyamine Salts of a Linoleic Acid Dimer for Topical Prophylaxis. / Orchard, Susan; Fellman, Jack H.; Storrs, Frances.

In: Archives of Dermatology, Vol. 122, No. 7, 1986, p. 783-789.

Research output: Contribution to journalArticle

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