TY - JOUR
T1 - Plus Disease in Retinopathy of Prematurity
T2 - Diagnostic Trends in 2016 Versus 2007
AU - Imaging & Informatics in ROP Research Consortium
AU - Moleta, Chace
AU - Campbell, J. Peter
AU - Kalpathy-Cramer, Jayashree
AU - Chan, R. V.Paul
AU - Ostmo, Susan
AU - Jonas, Karyn
AU - Chiang, Michael F.
AU - Chiang, Michael F.
AU - Ostmo, Susan
AU - Sonmez, Kemal
AU - Campbell, J. Peter
AU - Jonas, Karyn
AU - Horowitz, Jason
AU - Coki, Osode
AU - Eccles, Cheryl Ann
AU - Sarna, Leora
AU - Berrocal, Audina
AU - Negron, Catherin
AU - Denser, Kimberly
AU - Cumming, Kristi
AU - Osentoski, Tammy
AU - Check, Tammy
AU - Zajechowski, Mary
AU - Lee, Thomas
AU - Kruger, Evan
AU - McGovern, Kathryn
AU - Simmons, Charles
AU - Murthy, Raghu
AU - Galvis, Sharon
AU - Rotter, Jerome
AU - Chen, Ida
AU - Li, Xiaohui
AU - Taylor, Kent
AU - Roll, Kaye
AU - Kalpathy-Cramer, Jayashree
AU - Erdogmus, Deniz
AU - Ioannidis, Stratis
AU - Martinez-Castellanos, Maria Ana
AU - Salinas-Longoria, Samantha
AU - Romero, Rafael
AU - Arriola, Andrea
AU - Olguin-Manriquez, Francisco
AU - Meraz-Gutierrez, Miroslava
AU - Dulanto-Reinoso, Carlos M.
AU - Montero-Mendoza, Cristina
N1 - Publisher Copyright:
© 2017 Elsevier Inc.
PY - 2017/4/1
Y1 - 2017/4/1
N2 - Purpose To identify any temporal trends in the diagnosis of plus disease in retinopathy of prematurity (ROP) by experts. Design Reliability analysis. Methods ROP experts were recruited in 2007 and 2016 to classify 34 wide-field fundus images of ROP as plus, pre-plus, or normal, coded as “3,” “2,” and “1,” respectively, in the database. The main outcome was the average calculated score for each image in each cohort. Secondary outcomes included correlation on the relative ordering of the images in 2016 vs 2007, interexpert agreement, and intraexpert agreement. Results The average score for each image was higher for 30 of 34 (88%) images in 2016 compared with 2007, influenced by fewer images classified as normal (P < .01), a similar number of pre-plus (P = .52), and more classified as plus (P < .01). The mean weighted kappa values in 2006 were 0.36 (range 0.21–0.60), compared with 0.22 (range 0–0.40) in 2016. There was good correlation between rankings of disease severity between the 2 cohorts (Spearman rank correlation ρ = 0.94), indicating near-perfect agreement on relative disease severity. Conclusions Despite good agreement between cohorts on relative disease severity ranking, the higher average score and classifications for each image demonstrate that experts are diagnosing pre-plus and plus disease at earlier stages of disease severity in 2016, compared with 2007. This has implications for patient care, research, and teaching, and additional studies are needed to better understand this temporal trend in image-based plus disease diagnosis.
AB - Purpose To identify any temporal trends in the diagnosis of plus disease in retinopathy of prematurity (ROP) by experts. Design Reliability analysis. Methods ROP experts were recruited in 2007 and 2016 to classify 34 wide-field fundus images of ROP as plus, pre-plus, or normal, coded as “3,” “2,” and “1,” respectively, in the database. The main outcome was the average calculated score for each image in each cohort. Secondary outcomes included correlation on the relative ordering of the images in 2016 vs 2007, interexpert agreement, and intraexpert agreement. Results The average score for each image was higher for 30 of 34 (88%) images in 2016 compared with 2007, influenced by fewer images classified as normal (P < .01), a similar number of pre-plus (P = .52), and more classified as plus (P < .01). The mean weighted kappa values in 2006 were 0.36 (range 0.21–0.60), compared with 0.22 (range 0–0.40) in 2016. There was good correlation between rankings of disease severity between the 2 cohorts (Spearman rank correlation ρ = 0.94), indicating near-perfect agreement on relative disease severity. Conclusions Despite good agreement between cohorts on relative disease severity ranking, the higher average score and classifications for each image demonstrate that experts are diagnosing pre-plus and plus disease at earlier stages of disease severity in 2016, compared with 2007. This has implications for patient care, research, and teaching, and additional studies are needed to better understand this temporal trend in image-based plus disease diagnosis.
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U2 - 10.1016/j.ajo.2016.12.025
DO - 10.1016/j.ajo.2016.12.025
M3 - Article
C2 - 28087400
AN - SCOPUS:85010285162
SN - 0002-9394
VL - 176
SP - 70
EP - 76
JO - American journal of ophthalmology
JF - American journal of ophthalmology
ER -