Plus disease diagnosis in retinopathy of prematurity: Vascular tortuosity as a function of distance from optic disk

Katie M. Keck, Jayashree Kalpathy-Cramer, Esra Ataer-Cansizoglu, Sheng You, Deniz Erdogmus, Michael Chiang

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

PURPOSE:: To examine vascular tortuosity as a function of distance from the optic disk in infants with retinopathy of prematurity. METHODS:: Thirty-four wide-angle retinal images from infants with retinopathy of prematurity were reviewed by 22 experts. A reference standard for each image was defined as the diagnosis (plus vs. not plus) given by the majority of experts. Tortuosity, defined as vessel length divided by straight line distance between vessel end points, was calculated as a function of distance from the disk margin for arteries and veins using computer-based methods developed by the authors. RESULTS:: Mean cumulative tortuosity increased with distance from the disk margin, both in 13 images with plus disease (P = 0.007 for arterial tortuosity [n = 62 arteries], P <0.001 for venous tortuosity [n = 58 veins] based on slope of best fit line by regression), and in 21 images without plus disease (P <0.001 for arterial tortuosity [n = 94 arteries], P

Original languageEnglish (US)
Pages (from-to)1700-1707
Number of pages8
JournalRetina
Volume33
Issue number8
DOIs
StatePublished - Sep 2013

Fingerprint

Retinopathy of Prematurity
Optic Disk
Blood Vessels
Arteries
Veins
Arterial Tortuosity Syndrome

Keywords

  • medical informatics
  • pediatric ophthalmology
  • retina
  • retinopathy of prematurity

ASJC Scopus subject areas

  • Ophthalmology

Cite this

Plus disease diagnosis in retinopathy of prematurity : Vascular tortuosity as a function of distance from optic disk. / Keck, Katie M.; Kalpathy-Cramer, Jayashree; Ataer-Cansizoglu, Esra; You, Sheng; Erdogmus, Deniz; Chiang, Michael.

In: Retina, Vol. 33, No. 8, 09.2013, p. 1700-1707.

Research output: Contribution to journalArticle

Keck, Katie M. ; Kalpathy-Cramer, Jayashree ; Ataer-Cansizoglu, Esra ; You, Sheng ; Erdogmus, Deniz ; Chiang, Michael. / Plus disease diagnosis in retinopathy of prematurity : Vascular tortuosity as a function of distance from optic disk. In: Retina. 2013 ; Vol. 33, No. 8. pp. 1700-1707.
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