PLTP activity decreases with weight loss: Changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity

Susan J. Murdoch, Steven E. Kahn, John J. Albers, John D. Brunzell, Jonathan Purnell

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Phospholipid transfer protein (PLTP) activity is elevated in obese and diabetic subjects. No prospective studies have examined the effect of weight loss on PLTP activity and assessed whether the resultant changes in activity are related to changes in body weight, insulin resistance, or both. PLTP activity was measured at baseline in 46 subjects (body mass index = 19-64 kg/m2) and after diet-induced weight loss in 19 of the obese subjects. Total body fat mass (FM) by dual-energy X-ray absorptiometry, intraabdominal fat (IAF), and abdominal subcutaneous fat (SQF) by CT scan, insulin sensitivity (SI) by frequently sampled intravenous glucose tolerance test, leptin, and lipids were determined. At baseline, PLTP activity correlated with FM (r = 0.36, P = 0.02) and SQF (r = 0.31, P = 0.045), but not with IAF (r = 0.16, P = 0.32) or SI (r = 0.10, P = 0.52). With diet-induced weight loss (16 ± 7.3 kg), PLTP activity significantly decreased 9.1% (P = 0.002). The change in PLTP activity correlated with the change in SQF (r = 0.55, P = 0.014) (33.6% decrease), but not with IAF (r = 0.09, P = 0.73) or SI (r = 0.18, P = 0.44), and was highly correlated with the change in nonesterified fatty acid (NEFA) (r = 0.71, P <0.001). In conclusion, elevated PLTP activity in obese subjects is likely a result of increased body fat, reflected by SQF, and is influenced by NEFAs but is not directly related to insulin resistance.-Murdoch, S. J., S. E. Kahn, J. J. Albers, J. D. Brunzell, and J. Q. Purnell. PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity.

Original languageEnglish (US)
Pages (from-to)1705-1712
Number of pages8
JournalJournal of Lipid Research
Volume44
Issue number9
DOIs
StatePublished - Sep 1 2003

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Phospholipid Transfer Proteins
Subcutaneous Fat
Insulin Resistance
Weight Loss
Fats
Insulin
Reducing Diet
Nutrition
Nonesterified Fatty Acids
Adipose Tissue
Abdominal Subcutaneous Fat
Body Weight Changes
Computerized tomography
Photon Absorptiometry
Glucose Tolerance Test
Leptin
Body Mass Index
Prospective Studies
Lipids
Glucose

Keywords

  • Diabetes
  • Free fatty acid
  • Intraabdominal fat
  • Leptin
  • Obesity
  • Phospholipid transfer protein

ASJC Scopus subject areas

  • Endocrinology

Cite this

PLTP activity decreases with weight loss : Changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity. / Murdoch, Susan J.; Kahn, Steven E.; Albers, John J.; Brunzell, John D.; Purnell, Jonathan.

In: Journal of Lipid Research, Vol. 44, No. 9, 01.09.2003, p. 1705-1712.

Research output: Contribution to journalArticle

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abstract = "Phospholipid transfer protein (PLTP) activity is elevated in obese and diabetic subjects. No prospective studies have examined the effect of weight loss on PLTP activity and assessed whether the resultant changes in activity are related to changes in body weight, insulin resistance, or both. PLTP activity was measured at baseline in 46 subjects (body mass index = 19-64 kg/m2) and after diet-induced weight loss in 19 of the obese subjects. Total body fat mass (FM) by dual-energy X-ray absorptiometry, intraabdominal fat (IAF), and abdominal subcutaneous fat (SQF) by CT scan, insulin sensitivity (SI) by frequently sampled intravenous glucose tolerance test, leptin, and lipids were determined. At baseline, PLTP activity correlated with FM (r = 0.36, P = 0.02) and SQF (r = 0.31, P = 0.045), but not with IAF (r = 0.16, P = 0.32) or SI (r = 0.10, P = 0.52). With diet-induced weight loss (16 ± 7.3 kg), PLTP activity significantly decreased 9.1{\%} (P = 0.002). The change in PLTP activity correlated with the change in SQF (r = 0.55, P = 0.014) (33.6{\%} decrease), but not with IAF (r = 0.09, P = 0.73) or SI (r = 0.18, P = 0.44), and was highly correlated with the change in nonesterified fatty acid (NEFA) (r = 0.71, P <0.001). In conclusion, elevated PLTP activity in obese subjects is likely a result of increased body fat, reflected by SQF, and is influenced by NEFAs but is not directly related to insulin resistance.-Murdoch, S. J., S. E. Kahn, J. J. Albers, J. D. Brunzell, and J. Q. Purnell. PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity.",
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AU - Purnell, Jonathan

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N2 - Phospholipid transfer protein (PLTP) activity is elevated in obese and diabetic subjects. No prospective studies have examined the effect of weight loss on PLTP activity and assessed whether the resultant changes in activity are related to changes in body weight, insulin resistance, or both. PLTP activity was measured at baseline in 46 subjects (body mass index = 19-64 kg/m2) and after diet-induced weight loss in 19 of the obese subjects. Total body fat mass (FM) by dual-energy X-ray absorptiometry, intraabdominal fat (IAF), and abdominal subcutaneous fat (SQF) by CT scan, insulin sensitivity (SI) by frequently sampled intravenous glucose tolerance test, leptin, and lipids were determined. At baseline, PLTP activity correlated with FM (r = 0.36, P = 0.02) and SQF (r = 0.31, P = 0.045), but not with IAF (r = 0.16, P = 0.32) or SI (r = 0.10, P = 0.52). With diet-induced weight loss (16 ± 7.3 kg), PLTP activity significantly decreased 9.1% (P = 0.002). The change in PLTP activity correlated with the change in SQF (r = 0.55, P = 0.014) (33.6% decrease), but not with IAF (r = 0.09, P = 0.73) or SI (r = 0.18, P = 0.44), and was highly correlated with the change in nonesterified fatty acid (NEFA) (r = 0.71, P <0.001). In conclusion, elevated PLTP activity in obese subjects is likely a result of increased body fat, reflected by SQF, and is influenced by NEFAs but is not directly related to insulin resistance.-Murdoch, S. J., S. E. Kahn, J. J. Albers, J. D. Brunzell, and J. Q. Purnell. PLTP activity decreases with weight loss: changes in PLTP are associated with changes in subcutaneous fat and FFA but not IAF or insulin sensitivity.

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