TY - JOUR
T1 - Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography
AU - Gao, Liqin
AU - Wang, Jie
AU - You, Qisheng
AU - Guo, Yukun
AU - Flaxel, Christina J.
AU - Hwang, Thomas S.
AU - Huang, David
AU - Jia, Yali
AU - Bailey, Steven T.
N1 - Publisher Copyright:
© Author(s) (or their employer(s)) 2020. No commercial re-use. See rights and permissions. Published by BMJ.
Copyright:
Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020
Y1 - 2020
N2 - Objective: To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA). Methods and analysis: In this prospective cross-sectional single centre study, eyes with treatment-naïve EAMD underwent macular 3×3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively. Results: Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm2, p=0.006), ICP (0.016 vs 0.000 mm2, p=0.004) and DCP (0.033 vs 0.000 mm2, pï 1/4 0.001). Conclusion: PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.
AB - Objective: To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA). Methods and analysis: In this prospective cross-sectional single centre study, eyes with treatment-naïve EAMD underwent macular 3×3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively. Results: Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm2, p=0.006), ICP (0.016 vs 0.000 mm2, p=0.004) and DCP (0.033 vs 0.000 mm2, pï 1/4 0.001). Conclusion: PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.
KW - imaging
KW - macula
KW - neovascularisation
KW - retina
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U2 - 10.1136/bjophthalmol-2020-317562
DO - 10.1136/bjophthalmol-2020-317562
M3 - Article
AN - SCOPUS:85098248165
JO - British Journal of Ophthalmology
JF - British Journal of Ophthalmology
SN - 0007-1161
M1 - bjophthalmol-2020-317562
ER -