Plexus-specific retinal capillary avascular area in exudative age-related macular degeneration with projection-resolved OCT angiography

Liqin Gao, Jie Wang, Qisheng You, Yukun Guo, Christina Flaxel, Thomas Hwang, David Huang, Yali Jia, Steven T. Bailey

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: To detect the plexus-specific retinal capillary avascular area in exudative age-related macular degeneration (EAMD) with projection-resolved optical coherence tomography angiography (PR-OCTA). Methods and analysis: In this prospective cross-sectional single centre study, eyes with treatment-naïve EAMD underwent macular 3×3 mm OCTA with AngioVue system. OCTA scans were analysed and processed including three-dimensional projection artefact removal, retinal layer semi-automated segmentation and en face angiogram generation. Automated quantification of extrafoveal (excluding the central 1 mm circle) avascular area (EAA) were calculated on projection-resolved superficial vascular complex (SVC), intermediate capillary plexus (ICP) and deep capillary plexus (DCP), respectively. Results: Nineteen eyes with EAMD and 19 age-matched healthy control eyes were included. There was no significant difference between the EAMD and control eyes in terms of age, sex, axial length and mean ocular perfusion pressure (all p>0.05). Compared with control eyes, EAMD eyes had significantly larger EAA in SVC (median 0.125 vs 0.059 mm2, p=0.006), ICP (0.016 vs 0.000 mm2, p=0.004) and DCP (0.033 vs 0.000 mm2, pï 1/4 0.001). Conclusion: PR-OCTA showed that EAMD is associated with focal avascular area in all the three retinal vascular plexuses.

Original languageEnglish (US)
Article numberbjophthalmol-2020-317562
JournalBritish Journal of Ophthalmology
DOIs
StateAccepted/In press - 2020

Keywords

  • imaging
  • macula
  • neovascularisation
  • retina

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

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