Plerixafor Plus Granulocyte Colony-Stimulating Factor Improves the Mobilization of Hematopoietic Stem Cells in Patients with Non-Hodgkin Lymphoma and Low Circulating Peripheral Blood CD34+ Cells

Richard Maziarz, Auayporn P. Nademanee, Ivana N. Micallef, Patrick J. Stiff, Gary Calandra, Jennifer Angell, John F. DiPersio, Brian J. Bolwell

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Many institutions have adopted algorithms based on preapheresis circulating CD34+ cell counts to optimize the use of plerixafor. However, a circulating peripheral blood CD34+ cell threshold that predicts mobilization failure has not been defined. The superiority of plerixafor + granulocyte colony-stimulating factor (G-CSF) over placebo + G-CSF for hematopoietic stem cell mobilization and collection was shown for patients with non-Hodgkin lymphoma in a phase III, prospective, randomized, controlled study. The question remains as to which patients may benefit most from the use of plerixafor. In this post hoc retrospective analysis, mobilization outcomes were compared between the 2 treatment arms in patients stratified by peripheral blood CD34+ cell count (

Original languageEnglish (US)
Pages (from-to)670-675
Number of pages6
JournalBiology of Blood and Marrow Transplantation
Volume19
Issue number4
DOIs
StatePublished - Apr 2013

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Hematopoietic Stem Cell Mobilization
Granulocyte Colony-Stimulating Factor
Non-Hodgkin's Lymphoma
Blood Cells
Blood Cell Count
Cell Count
Placebos
JM 3100
Therapeutics

Keywords

  • Non-Hodgkin lymphoma
  • Peripheral blood stem cell mobilization
  • Plerixafor

ASJC Scopus subject areas

  • Transplantation
  • Hematology

Cite this

Plerixafor Plus Granulocyte Colony-Stimulating Factor Improves the Mobilization of Hematopoietic Stem Cells in Patients with Non-Hodgkin Lymphoma and Low Circulating Peripheral Blood CD34+ Cells. / Maziarz, Richard; Nademanee, Auayporn P.; Micallef, Ivana N.; Stiff, Patrick J.; Calandra, Gary; Angell, Jennifer; DiPersio, John F.; Bolwell, Brian J.

In: Biology of Blood and Marrow Transplantation, Vol. 19, No. 4, 04.2013, p. 670-675.

Research output: Contribution to journalArticle

Maziarz, Richard ; Nademanee, Auayporn P. ; Micallef, Ivana N. ; Stiff, Patrick J. ; Calandra, Gary ; Angell, Jennifer ; DiPersio, John F. ; Bolwell, Brian J. / Plerixafor Plus Granulocyte Colony-Stimulating Factor Improves the Mobilization of Hematopoietic Stem Cells in Patients with Non-Hodgkin Lymphoma and Low Circulating Peripheral Blood CD34+ Cells. In: Biology of Blood and Marrow Transplantation. 2013 ; Vol. 19, No. 4. pp. 670-675.
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