Pleiotropic signaling pathways in rapid, nongenomic action of glucocorticoid

Yi Zhang Chen, Jian Qiu

Research output: Contribution to journalArticle

60 Scopus citations

Abstract

The traditional genomic theory of steroid action does not fully explain the rapid effects of hormonal steroids, and it is thought that the nongenomic actions mediated by a putative membrane receptor may provide a plausible explanation. Although there is a rich body of evidence to substantiate the rapid, nongenomic effects of steroid hormones, the signal transduction pathways involved have proved to be complex and pleiotropic. Based on previous studies on the rapid, nongenomic actions of glucocorticoid (GC) and the G-protein-protein kinase pathways involved, including our own studies on PC12, SK-N-SH, BT-325 cells, and synaptosomes, in this review we will discuss the issue of multiple signal transduction pathways involved in the rapid, nongenomic effects of GC.

Original languageEnglish (US)
Pages (from-to)145-149
Number of pages5
JournalMolecular Cell Biology Research Communications
Volume2
Issue number3
DOIs
StatePublished - Sep 1999

Keywords

  • Cells
  • Glucocorticoid
  • Nongenomic
  • Pleotropic
  • Receptor
  • Signal transduction

ASJC Scopus subject areas

  • Molecular Biology

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