Platelet response to acute blood loss: An experimental study

Robert C. Lim, James W. Holcroft, Donald D. Trunkey

    Research output: Contribution to journalArticlepeer-review


    The platelet changes associated with acute blood loss were studied in dogs and baboons. The circulating platelets decreased and aggregability increased in response to hemorrhage. Intrinsic ATP and ADP concentrations and ultrastructural morphology did not change significantly. These results explain, in part, the coagulopathy that occurs in the trauma victim in hemorrhagic shock. Based upon these observations, the authors describe a resuscitative program that includes whole blood and platelet administration.

    Original languageEnglish (US)
    Pages (from-to)524-527
    Number of pages4
    JournalJournal of the American College of Emergency Physicians
    Issue number6
    StatePublished - 1975


    • blood, clotting
    • blood, platelet
    • shock, hemorrhagic
    • shock, hypovolemic

    ASJC Scopus subject areas

    • Critical Care and Intensive Care Medicine


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