Platelet response to acute blood loss: An experimental study

Robert C. Lim, James W. Holcroft, Donald Trunkey

Research output: Contribution to journalArticle


The platelet changes associated with acute blood loss were studied in dogs and baboons. The circulating platelets decreased and aggregability increased in response to hemorrhage. Intrinsic ATP and ADP concentrations and ultrastructural morphology did not change significantly. These results explain, in part, the coagulopathy that occurs in the trauma victim in hemorrhagic shock. Based upon these observations, the authors describe a resuscitative program that includes whole blood and platelet administration.

Original languageEnglish (US)
Pages (from-to)524-527
Number of pages4
JournalJournal of the American College of Emergency Physicians
Issue number6
Publication statusPublished - 1975
Externally publishedYes



  • blood, clotting
  • blood, platelet
  • shock, hemorrhagic
  • shock, hypovolemic

ASJC Scopus subject areas

  • Critical Care and Intensive Care Medicine

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