Platelet response to acute blood loss: An experimental study

Robert C. Lim; James W. Holcroft; Donald Trunkey

doi:10.1016/S0361-1124(75)80032-3

Platelet response to acute blood loss: An experimental study

Robert C. Lim, James W. Holcroft, Donald Trunkey

Research output: Contribution to journal › Article

Abstract

The platelet changes associated with acute blood loss were studied in dogs and baboons. The circulating platelets decreased and aggregability increased in response to hemorrhage. Intrinsic ATP and ADP concentrations and ultrastructural morphology did not change significantly. These results explain, in part, the coagulopathy that occurs in the trauma victim in hemorrhagic shock. Based upon these observations, the authors describe a resuscitative program that includes whole blood and platelet administration.

Original language	English (US)
Pages (from-to)	524-527
Number of pages	4
Journal	Journal of the American College of Emergency Physicians
Volume	4
Issue number	6
DOIs	https://doi.org/10.1016/S0361-1124(75)80032-3
Publication status	Published - 1975
Externally published	Yes

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Keywords

blood, clotting
blood, platelet
shock, hemorrhagic
shock, hypovolemic

ASJC Scopus subject areas

Critical Care and Intensive Care Medicine

Cite this

Lim, R. C., Holcroft, J. W., & Trunkey, D. (1975). Platelet response to acute blood loss: An experimental study. Journal of the American College of Emergency Physicians, 4(6), 524-527. https://doi.org/10.1016/S0361-1124(75)80032-3

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10.1016/S0361-1124(75)80032-3