Abstract
The platelet changes associated with acute blood loss were studied in dogs and baboons. The circulating platelets decreased and aggregability increased in response to hemorrhage. Intrinsic ATP and ADP concentrations and ultrastructural morphology did not change significantly. These results explain, in part, the coagulopathy that occurs in the trauma victim in hemorrhagic shock. Based upon these observations, the authors describe a resuscitative program that includes whole blood and platelet administration.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 524-527 |
| Number of pages | 4 |
| Journal | Journal of the American College of Emergency Physicians |
| Volume | 4 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jan 1 1975 |
Keywords
- blood, clotting
- blood, platelet
- shock, hemorrhagic
- shock, hypovolemic
ASJC Scopus subject areas
- Critical Care and Intensive Care Medicine
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Cite this
Lim, R. C., Holcroft, J. W., & Trunkey, D. D. (1975). Platelet response to acute blood loss: An experimental study. Journal of the American College of Emergency Physicians, 4(6), 524-527. https://doi.org/10.1016/S0361-1124(75)80032-3