Platelet monoamine oxidase activity in the psychoses: Relationship to symptoms and lithium response

Robert J. Hitzemann; Frederick Sautter; Barbara Hitzemann; Jack Hirschowitz; David L. Garver

doi:10.1016/0165-1781(84)90070-2

Platelet monoamine oxidase activity in the psychoses: Relationship to symptoms and lithium response

Robert J. Hitzemann, Frederick Sautter, Barbara Hitzemann, Jack Hirschowitz, David L. Garver

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

The kinetics of platelet monoamine oxidase (MAO) were studied in 100 psychotic and manic patients and 36 controls. No relationship was found between MAO activity and response to lithium in the schizophrenic-like illnesses. However, the data do suggest there is an association between enzyme affinity (K_m) and specific symptom clusters. Patients with the low K_m variant of platelet MAO are enriched in depressive symptoms, while those with the high K_m variant are enriched in manic symptoms.

Original language	English (US)
Pages (from-to)	211-221
Number of pages	11
Journal	Psychiatry Research
Volume	11
Issue number	3
DOIs	https://doi.org/10.1016/0165-1781(84)90070-2
State	Published - Mar 1984
Externally published	Yes

Keywords

Platelet monoamine oxidase
enzyme kinetics
lithium
psychoses
symptom clusters

ASJC Scopus subject areas

Psychiatry and Mental health
Biological Psychiatry

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10.1016/0165-1781(84)90070-2

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title = "Platelet monoamine oxidase activity in the psychoses: Relationship to symptoms and lithium response",

abstract = "The kinetics of platelet monoamine oxidase (MAO) were studied in 100 psychotic and manic patients and 36 controls. No relationship was found between MAO activity and response to lithium in the schizophrenic-like illnesses. However, the data do suggest there is an association between enzyme affinity (Km) and specific symptom clusters. Patients with the low Km variant of platelet MAO are enriched in depressive symptoms, while those with the high Km variant are enriched in manic symptoms.",

keywords = "Platelet monoamine oxidase, enzyme kinetics, lithium, psychoses, symptom clusters",

author = "Hitzemann, {Robert J.} and Frederick Sautter and Barbara Hitzemann and Jack Hirschowitz and Garver, {David L.}",

note = "Funding Information: Acknowledgments. The authorst hank Ruth Morris for editorial and typing assistance.T he research reported was supported in part by USPHS grants MH-37377 (RH) and MH-32666 (DC).",

year = "1984",

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AU - Hitzemann, Robert J.

AU - Sautter, Frederick

AU - Hitzemann, Barbara

AU - Hirschowitz, Jack

AU - Garver, David L.

N1 - Funding Information: Acknowledgments. The authorst hank Ruth Morris for editorial and typing assistance.T he research reported was supported in part by USPHS grants MH-37377 (RH) and MH-32666 (DC).

PY - 1984/3

Y1 - 1984/3

N2 - The kinetics of platelet monoamine oxidase (MAO) were studied in 100 psychotic and manic patients and 36 controls. No relationship was found between MAO activity and response to lithium in the schizophrenic-like illnesses. However, the data do suggest there is an association between enzyme affinity (Km) and specific symptom clusters. Patients with the low Km variant of platelet MAO are enriched in depressive symptoms, while those with the high Km variant are enriched in manic symptoms.

AB - The kinetics of platelet monoamine oxidase (MAO) were studied in 100 psychotic and manic patients and 36 controls. No relationship was found between MAO activity and response to lithium in the schizophrenic-like illnesses. However, the data do suggest there is an association between enzyme affinity (Km) and specific symptom clusters. Patients with the low Km variant of platelet MAO are enriched in depressive symptoms, while those with the high Km variant are enriched in manic symptoms.

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KW - enzyme kinetics

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KW - psychoses

KW - symptom clusters

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Platelet monoamine oxidase activity in the psychoses: Relationship to symptoms and lithium response

Abstract

Keywords

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