Platelet monoamine oxidase activity in the psychoses: Relationship to symptoms and lithium response

Robert J. Hitzemann, Frederick Sautter, Barbara Hitzemann, Jack Hirschowitz, David L. Garver

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2 Scopus citations


The kinetics of platelet monoamine oxidase (MAO) were studied in 100 psychotic and manic patients and 36 controls. No relationship was found between MAO activity and response to lithium in the schizophrenic-like illnesses. However, the data do suggest there is an association between enzyme affinity (Km) and specific symptom clusters. Patients with the low Km variant of platelet MAO are enriched in depressive symptoms, while those with the high Km variant are enriched in manic symptoms.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalPsychiatry Research
Issue number3
StatePublished - Mar 1984



  • Platelet monoamine oxidase
  • enzyme kinetics
  • lithium
  • psychoses
  • symptom clusters

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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