Platelet monoamine oxidase activity in the psychoses: Relationship to symptoms and lithium response

Robert Hitzemann, Frederick Sautter, Barbara Hitzemann, Jack Hirschowitz, David L. Garver

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The kinetics of platelet monoamine oxidase (MAO) were studied in 100 psychotic and manic patients and 36 controls. No relationship was found between MAO activity and response to lithium in the schizophrenic-like illnesses. However, the data do suggest there is an association between enzyme affinity (Km) and specific symptom clusters. Patients with the low Km variant of platelet MAO are enriched in depressive symptoms, while those with the high Km variant are enriched in manic symptoms.

Original languageEnglish (US)
Pages (from-to)211-221
Number of pages11
JournalPsychiatry Research
Volume11
Issue number3
DOIs
StatePublished - 1984
Externally publishedYes

Fingerprint

Monoamine Oxidase
Lithium
Psychotic Disorders
Blood Platelets
Depression
Enzymes

Keywords

  • enzyme kinetics
  • lithium
  • Platelet monoamine oxidase
  • psychoses
  • symptom clusters

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry
  • Psychology(all)

Cite this

Platelet monoamine oxidase activity in the psychoses : Relationship to symptoms and lithium response. / Hitzemann, Robert; Sautter, Frederick; Hitzemann, Barbara; Hirschowitz, Jack; Garver, David L.

In: Psychiatry Research, Vol. 11, No. 3, 1984, p. 211-221.

Research output: Contribution to journalArticle

Hitzemann, Robert ; Sautter, Frederick ; Hitzemann, Barbara ; Hirschowitz, Jack ; Garver, David L. / Platelet monoamine oxidase activity in the psychoses : Relationship to symptoms and lithium response. In: Psychiatry Research. 1984 ; Vol. 11, No. 3. pp. 211-221.
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