TY - JOUR
T1 - Platelet Membrane Lipid Composition and the Frequency of Migraine
AU - Oxman, Thomas E.
AU - Hitzemann, Robert J.
AU - Smith, Robert
N1 - Copyright:
Copyright 2016 Elsevier B.V., All rights reserved.
PY - 1982/11
Y1 - 1982/11
N2 - SYNOPSIS A variety of evidence associates abnormalities in platelet function with the development of migraine. Given the pivotal role of platelet membranes in these functions, it was proposed that migraine patients have abnormalities in their platelet membrane composition. To examine this hypothesis, platelet membrane lipid composition was analyzed in 16 migraine patients and 10 control subjects. The content of phosphatidylcholine, the amount of arachidonic acid in phosphatidylcholine, and the amount of unsaturated fatty acids in most phospholipids were significantly increased in patients with infrequent migraine as compared to controls or patients with frequent migraine. These results suggest that membrane lipid composition may play a role in the frequency and severity of migraine attacks.
AB - SYNOPSIS A variety of evidence associates abnormalities in platelet function with the development of migraine. Given the pivotal role of platelet membranes in these functions, it was proposed that migraine patients have abnormalities in their platelet membrane composition. To examine this hypothesis, platelet membrane lipid composition was analyzed in 16 migraine patients and 10 control subjects. The content of phosphatidylcholine, the amount of arachidonic acid in phosphatidylcholine, and the amount of unsaturated fatty acids in most phospholipids were significantly increased in patients with infrequent migraine as compared to controls or patients with frequent migraine. These results suggest that membrane lipid composition may play a role in the frequency and severity of migraine attacks.
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U2 - 10.1111/j.1526-4610.1982.hed2206261.x
DO - 10.1111/j.1526-4610.1982.hed2206261.x
M3 - Article
C2 - 7174303
AN - SCOPUS:0020431953
SN - 0017-8748
VL - 22
SP - 261
EP - 267
JO - Headache: The Journal of Head and Face Pain
JF - Headache: The Journal of Head and Face Pain
IS - 6
ER -