Platelet FcγRIIA Receptor Surface Expression Is Increased in Patients With ESRD and Is Associated With Atherosclerotic Cardiovascular Events

Mohamed El-Shahawy, Mazen Noureddin, Hesham Abdullah, Wendy J. Mack, David Calverley

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background: Accelerated atherogenesis is a prominent feature of end-stage renal disease (ESRD). Methods: Expression of platelet FcγRIIA immunoglobulin G receptor (FcγR) was measured in 2 populations: (1) 48 patients with ESRD with a mean age of 50.7 ± 2.3 (SEM) years and (2) 48 healthy age- and sex-matched controls aged 53.6 ± 1.6 years. Results: Platelet FcγR expression was enhanced significantly in patients with ESRD (mean fluorescence intensity [MFI], 7.88 ± 0.42 [SEM]; 95% confidence interval [CI], 7.03 to 8.72 versus 5.07 ± 0.21; 95% CI, 4.64 to 5.49; P <0.0001). In patients with ESRD, multivariate analysis showed that hemoglobin level and diastolic blood pressure were related inversely to FCγR expression (P = 0.01 and P = 0.03, respectively). Atherosclerotic cardiovascular events (ACVEs) were recorded prospectively for the ESRD cohort. A total of 22 ACVEs, defined as the occurrence of myocardial infarction (10 events), cerebrovascular accident (7 events), and/or a peripheral vascular event (5 events), were observed. In the group with greater receptor expression (MFI > 7.785; n = 24), 13 of 17 patients (76.5%) experienced at least 1 ACVE, whereas only 4 of 17 patients (23.5%) with low FcγR expression (MFI <7.785; n = 24) experienced an event (P = 0.007). Conclusion: (1) Uremia is associated with enhanced platelet FcγR expression, and (2) patients with greater platelet FcγR expression are significantly more likely to experience ACVEs; however, (3) the small sample size is a limitation and our work therefore is a hypothesis-generating pilot study that remains to be confirmed.

Original languageEnglish (US)
Pages (from-to)127-134
Number of pages8
JournalAmerican Journal of Kidney Diseases
Volume49
Issue number1
DOIs
StatePublished - Jan 2007
Externally publishedYes

Fingerprint

Chronic Kidney Failure
Blood Platelets
Fluorescence
Confidence Intervals
IgG Receptors
Uremia
Sample Size
Atherosclerosis
Population

Keywords

  • atherosclerosis
  • cardiovascular disease
  • end-stage renal disease (ESRD)
  • Kidney failure
  • myocardial ischemia
  • platelet Fcγ receptor
  • uremia

ASJC Scopus subject areas

  • Nephrology
  • Medicine(all)

Cite this

Platelet FcγRIIA Receptor Surface Expression Is Increased in Patients With ESRD and Is Associated With Atherosclerotic Cardiovascular Events. / El-Shahawy, Mohamed; Noureddin, Mazen; Abdullah, Hesham; Mack, Wendy J.; Calverley, David.

In: American Journal of Kidney Diseases, Vol. 49, No. 1, 01.2007, p. 127-134.

Research output: Contribution to journalArticle

El-Shahawy, Mohamed ; Noureddin, Mazen ; Abdullah, Hesham ; Mack, Wendy J. ; Calverley, David. / Platelet FcγRIIA Receptor Surface Expression Is Increased in Patients With ESRD and Is Associated With Atherosclerotic Cardiovascular Events. In: American Journal of Kidney Diseases. 2007 ; Vol. 49, No. 1. pp. 127-134.
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abstract = "Background: Accelerated atherogenesis is a prominent feature of end-stage renal disease (ESRD). Methods: Expression of platelet FcγRIIA immunoglobulin G receptor (FcγR) was measured in 2 populations: (1) 48 patients with ESRD with a mean age of 50.7 ± 2.3 (SEM) years and (2) 48 healthy age- and sex-matched controls aged 53.6 ± 1.6 years. Results: Platelet FcγR expression was enhanced significantly in patients with ESRD (mean fluorescence intensity [MFI], 7.88 ± 0.42 [SEM]; 95{\%} confidence interval [CI], 7.03 to 8.72 versus 5.07 ± 0.21; 95{\%} CI, 4.64 to 5.49; P <0.0001). In patients with ESRD, multivariate analysis showed that hemoglobin level and diastolic blood pressure were related inversely to FCγR expression (P = 0.01 and P = 0.03, respectively). Atherosclerotic cardiovascular events (ACVEs) were recorded prospectively for the ESRD cohort. A total of 22 ACVEs, defined as the occurrence of myocardial infarction (10 events), cerebrovascular accident (7 events), and/or a peripheral vascular event (5 events), were observed. In the group with greater receptor expression (MFI > 7.785; n = 24), 13 of 17 patients (76.5{\%}) experienced at least 1 ACVE, whereas only 4 of 17 patients (23.5{\%}) with low FcγR expression (MFI <7.785; n = 24) experienced an event (P = 0.007). Conclusion: (1) Uremia is associated with enhanced platelet FcγR expression, and (2) patients with greater platelet FcγR expression are significantly more likely to experience ACVEs; however, (3) the small sample size is a limitation and our work therefore is a hypothesis-generating pilot study that remains to be confirmed.",
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T1 - Platelet FcγRIIA Receptor Surface Expression Is Increased in Patients With ESRD and Is Associated With Atherosclerotic Cardiovascular Events

AU - El-Shahawy, Mohamed

AU - Noureddin, Mazen

AU - Abdullah, Hesham

AU - Mack, Wendy J.

AU - Calverley, David

PY - 2007/1

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N2 - Background: Accelerated atherogenesis is a prominent feature of end-stage renal disease (ESRD). Methods: Expression of platelet FcγRIIA immunoglobulin G receptor (FcγR) was measured in 2 populations: (1) 48 patients with ESRD with a mean age of 50.7 ± 2.3 (SEM) years and (2) 48 healthy age- and sex-matched controls aged 53.6 ± 1.6 years. Results: Platelet FcγR expression was enhanced significantly in patients with ESRD (mean fluorescence intensity [MFI], 7.88 ± 0.42 [SEM]; 95% confidence interval [CI], 7.03 to 8.72 versus 5.07 ± 0.21; 95% CI, 4.64 to 5.49; P <0.0001). In patients with ESRD, multivariate analysis showed that hemoglobin level and diastolic blood pressure were related inversely to FCγR expression (P = 0.01 and P = 0.03, respectively). Atherosclerotic cardiovascular events (ACVEs) were recorded prospectively for the ESRD cohort. A total of 22 ACVEs, defined as the occurrence of myocardial infarction (10 events), cerebrovascular accident (7 events), and/or a peripheral vascular event (5 events), were observed. In the group with greater receptor expression (MFI > 7.785; n = 24), 13 of 17 patients (76.5%) experienced at least 1 ACVE, whereas only 4 of 17 patients (23.5%) with low FcγR expression (MFI <7.785; n = 24) experienced an event (P = 0.007). Conclusion: (1) Uremia is associated with enhanced platelet FcγR expression, and (2) patients with greater platelet FcγR expression are significantly more likely to experience ACVEs; however, (3) the small sample size is a limitation and our work therefore is a hypothesis-generating pilot study that remains to be confirmed.

AB - Background: Accelerated atherogenesis is a prominent feature of end-stage renal disease (ESRD). Methods: Expression of platelet FcγRIIA immunoglobulin G receptor (FcγR) was measured in 2 populations: (1) 48 patients with ESRD with a mean age of 50.7 ± 2.3 (SEM) years and (2) 48 healthy age- and sex-matched controls aged 53.6 ± 1.6 years. Results: Platelet FcγR expression was enhanced significantly in patients with ESRD (mean fluorescence intensity [MFI], 7.88 ± 0.42 [SEM]; 95% confidence interval [CI], 7.03 to 8.72 versus 5.07 ± 0.21; 95% CI, 4.64 to 5.49; P <0.0001). In patients with ESRD, multivariate analysis showed that hemoglobin level and diastolic blood pressure were related inversely to FCγR expression (P = 0.01 and P = 0.03, respectively). Atherosclerotic cardiovascular events (ACVEs) were recorded prospectively for the ESRD cohort. A total of 22 ACVEs, defined as the occurrence of myocardial infarction (10 events), cerebrovascular accident (7 events), and/or a peripheral vascular event (5 events), were observed. In the group with greater receptor expression (MFI > 7.785; n = 24), 13 of 17 patients (76.5%) experienced at least 1 ACVE, whereas only 4 of 17 patients (23.5%) with low FcγR expression (MFI <7.785; n = 24) experienced an event (P = 0.007). Conclusion: (1) Uremia is associated with enhanced platelet FcγR expression, and (2) patients with greater platelet FcγR expression are significantly more likely to experience ACVEs; however, (3) the small sample size is a limitation and our work therefore is a hypothesis-generating pilot study that remains to be confirmed.

KW - atherosclerosis

KW - cardiovascular disease

KW - end-stage renal disease (ESRD)

KW - Kidney failure

KW - myocardial ischemia

KW - platelet Fcγ receptor

KW - uremia

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