Platelet FcγRIIA expression is associated with the α2 integrin C807T gene polymorphism in type 2 diabetes

David Calverley, Lyndy V. Baldermann, Kathleen Moran, Nancy N. Chen, Kim Mcfann

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

"Patelet" FcγRIIA is stably overexpressed in type 2 diabetes and may also play a role in collagen-mediated platelet activation. Platelet surface integrin α2β1-collagen interaction is an early step associated with platelet adhesion and activation and plays an important role in arterial thrombosis. The objective of this study was to characterize the relationship in diabetes and non-diabetes platelets between FcγRIIA expression and a polymorphism associated with arterial thrombotic events, polymorphism C807T on the gene encoding α 2β1. Platelet flow cytometry and allele-specific PCR revealed a significant correlation in type 2 diabetes between low platelet FcγRIIA expression and the 807TT genotype that is associated with increased platelet α2β1 receptor density. We conclude that uni- or bi-directional modulation of surface expression may exist between the platelet FcγRIIA receptor and a α2β 1 thrombogenic polymorphism that could play a role in platelet sensitivity to collagen in type 2 diabetes.

Original languageEnglish (US)
Pages (from-to)78-83
Number of pages6
JournalPlatelets
Volume17
Issue number2
DOIs
StatePublished - Mar 1 2006
Externally publishedYes

Fingerprint

Integrins
Type 2 Diabetes Mellitus
Blood Platelets
Genes
Platelet Activation
Collagen
Collagen Type II
Flow Cytometry
Thrombosis
Alleles
Genotype
Polymerase Chain Reaction

Keywords

  • Arterial thrombosis
  • Collagen
  • Diabetes mellitus
  • Platelets
  • Stroke

ASJC Scopus subject areas

  • Hematology
  • Cell Biology

Cite this

Platelet FcγRIIA expression is associated with the α2 integrin C807T gene polymorphism in type 2 diabetes. / Calverley, David; Baldermann, Lyndy V.; Moran, Kathleen; Chen, Nancy N.; Mcfann, Kim.

In: Platelets, Vol. 17, No. 2, 01.03.2006, p. 78-83.

Research output: Contribution to journalArticle

Calverley, David ; Baldermann, Lyndy V. ; Moran, Kathleen ; Chen, Nancy N. ; Mcfann, Kim. / Platelet FcγRIIA expression is associated with the α2 integrin C807T gene polymorphism in type 2 diabetes. In: Platelets. 2006 ; Vol. 17, No. 2. pp. 78-83.
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