Platelet Disorders

Research output: Contribution to journalArticlepeer-review

Abstract

After vascular injury and exposure of subendothelial matrix proteins to the intravascular space, mediators of hemostasis are triggered and allow for clot formation and restoration of vascular integrity. Platelets are the mediators of primary hemostasis, creating a platelet plug and allowing for initial cessation of bleeding. Platelet disorders, qualitative and quantitative, may result in bleeding signs and symptoms, particularly mucocutaneous bleeding such as epistaxis, bruising, petechiae, and heavy menstrual bleeding. Increasing evidence suggests that platelets have functional capabilities beyond hemostasis, but this review focuses solely on platelet hemostatic properties. Herein, normal platelet function as well as the effects of abnormal function and thrombocytopenia are reviewed.

Original languageEnglish (US)
Pages (from-to)224-235
Number of pages12
JournalPediatrics in review
Volume41
Issue number5
DOIs
StatePublished - May 1 2020

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health

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